Beth Saslow

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We describe two sisters with a mild-onset variant of Canavan's disease who presented at age 50 and 19 months with developmental delay but without macrocephaly, hypotonia, spasticity, or seizures. Remarkably, both patients had age-appropriate head control, gross motor development, and muscle tone. There were very mild deficits in fine motor skills,(More)
The present study was designed to examine the effects of the calcium entry blocker, nifedipine, on the acute depressor responses to alpha 2-adrenoceptor agonists. Conscious spontaneously hypertensive rats (SHR) were given nifedipine intravenously (25 micrograms/kg) or vehicle (polyethylene glycol). Subsequent intravenous administration of guanabenz (10, 25,(More)
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