Learn More
Pluripotent embryonic stem cells (ESCs) are known to possess a relatively open chromatin structure; yet, despite efforts to characterize the chromatin signatures of ESCs, the role of chromatin compaction in stem cell fate and function remains elusive. Linker histone H1 is important for higher-order chromatin folding and is essential for mammalian(More)
Role of linker histone H1 in epigenetic regulation of pluripotency genes and Hox genes To my father, Weijun Zhang. iv ACKNOWLEDGEMENTS First, I would like to thank my thesis advisor, Dr. Yuhong Fan, for her guidance, encouragement and support. My thesis work would not have been possible without her time, ideas and funding support. I have not only learned(More)
  • 1