Beta L Bowen

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OBJECTIVE To examine the safety of botulinum toxin type A (BTX-A). DESIGN Analysis of pooled data of 9 double-blind, placebo-controlled studies of patients with spasticity after stroke. SETTING University hospitals and specialty rehabilitation centers in the United States. PARTICIPANTS A total of 482 patients with upper-limb spasticity and 310 with(More)
Blood monocytes are the principal reservoir for tissue macrophages in rheumatoid synovitis. Receptor-mediated adhesive interactions between circulating cells and the synovial venules initiate recruitment. These interactions have been studied primarily in cultured endothelial cells. Thus the functional activities of specific adhesion receptors, such as the(More)
BACKGROUND OnabotulinumtoxinA for the treatment of facial lines is a widely used cosmetic medical procedure and, as such, the safety and tolerability profile is of interest to health care providers and patients. Based on data from individual studies that were conducted according to regulatory guidelines to provide adequate safety and efficacy data to(More)
INTRODUCTION no previously published botulinum toxin type A cosmetic trials included both physician and subject measures of onset. OBJECTIVE determine physician- and subject-reported onset of onabotulinumtoxinA. METHODS Two-center open-label, 14-day study in toxin-naive female patients with moderate-to-severe glabellar lines (GL) treated with 20-U(More)
Sections of lesional tissue from 6 patients who exhibited only oral lesions of lichen planus (LP) were incubated with autologous serum and studied immunopathologically for the presence of lichen planus specific antigen (LPSA). None of the specimens was positive for LPSA. Serum from the oral LP patients was subsequently incubated with allogeneic cutaneous LP(More)
Chloroplasts were isolated from pea and sunflower leaves having various water potentials. Oxygen evolution by the chloroplasts was measured under identical conditions for all treatments with saturating light and with dichloroindophenol as oxidant. Evolution was inhibited when leaf water potentials were below -12 bars in pea and -8 bars in sunflower and the(More)
The in vitro effects of 1,1-dimethylhydrazine (UDMH) on prostaglandin E(2) (PGE(2)) synthesis, chemiluminescence, phagocytosis, microbicidal activity and chemotaxis in murine enriched-macrophage populations were evaluated. PGE(2) synthesis by resident peritoneal macrophages and chemiluminescence by activated macrophages were markedly suppressed in the(More)
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