Bespalov AYu

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Development of tolerance to opiates involves various neurochemically and pharmacologically distinct processes. For instance, the diversity of opiate tolerance has been suggested by experiments comparing the establishment of diminished response to different effects of opiate agonists. Antagonists acting at N-methyl-D-aspartate (NMDA) receptors has become a(More)
The ability of morphine and amphetamine to potentiate brain stimulation reward was studied in rats with monopolar electrodes in the medial forebrain bundle. Animals received seven daily injections of morphine (3 mg/kg, s.c.) or saline followed 10 min later by either DNQX (100 mg/kg, i.p.) or its vehicle. On the 8th day the self-stimulation (SS) response was(More)
Two groups of rats with bipolar electrodes implanted unilaterally into the left ventral tegmental area were trained to lever-press for the response contingent electrical stimulation. After preliminary lever-press training, two types of daily sessions were held on 10 consecutive days: type T+, current intensity set at the Threshold level and each response(More)
The present study addressed the ability of the NMDA receptor antagonist (+/-)-CPP ((+/-)-3-(2-carboxy-piperazine-4-yl)-propyl-1-phosphonic acid) to block the expression of amphetamine (AMPH)-conditioned place preference (CPP) or pentylenetetrazol (PTZ)-conditioned place aversion (CPA) in male Wistar rats. During a 4-day conditioning period, daily injections(More)
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