Bertrand Viellerobe

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This paper presents an integrated endoscope-compatible Fibered Confocal Fluorescence Microscope (FCFM) for medical imaging, the F-400. In situ high resolution images can be obtained thanks to a set of flexible miniaturized optical probes of 0.5 to 1.5 mm diameter that can be inserted through the working channel of an endoscope. We briefly present in this(More)
A fluorescence lifetime imaging (FLIM) technology platform intended to read out changes in Förster resonance energy transfer (FRET) efficiency is presented for the study of protein interactions across the drug-discovery pipeline. FLIM provides a robust, inherently ratiometric imaging modality for drug discovery that could allow the same sensor constructs to(More)
We present an endomicroscope apparatus that utilizes structured illumination to produce high resolution (∼ 2.6μm) optically sectioned fluorescence images over a field of view of about 240μm. The endomicroscope is based on the use of a flexible imaging fiber bundle with a miniaturized objective. We also present a strategy to largely suppress structured(More)
Fibered confocal fluorescence microscopy (FCFM) is a new technique that can be used during a bronchoscopy to analyze the nature of the human bronchial and alveolar mucosa fluorescence microstructure. An endoscopic fibered confocal fluorescence microscopy system with spectroscopic analysis capability was developed allowing real-time, simultaneous images and(More)
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