Bertrand Lemieux

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Aspects of Evolutionary Computation, DNA computing, and in vitro evolution are combined in proposed laboratory procedures. Preliminary experimental results are shown. The traditional test problem for Evolutionary Computation known as the OneMax problem is addressed. The preliminary experimental results indicate successful laboratory separation by tness" of(More)
Genetic algorithms, DNA computing, and in vitro evolution are brieey discussed. Elements of these are combined into laboratory procedures, and preliminary results are shown. The traditional test problem for genetic algorithms called the MAX 1s problem is addressed. Preliminary experimental results indicate successful laboratory separation by tness" of DNA(More)
In vitro DNA amplification methods, such as polymerase chain reaction (PCR), rely on synthetic oligonucleotide primers for initiation of the reaction. In vivo, primers are synthesized on-template by DNA primase. The bacteriophage T7 gene 4 protein (gp4) has both primase and helicase activities. In this study, we report the development of a primase-based(More)
BACKGROUND In the past decades the rapid growth of molecular diagnostics (based on either traditional PCR or isothermal amplification technologies) meet the demand for fast and accurate testing. Although isothermal amplification technologies have the advantages of low cost requirements for instruments, the further improvement on sensitivity, speed and(More)
Consider the difficulty of designing DNA sequences such as that of the human genome which codes for approximately 100,000 proteins. Even a small protein of 300 amino acids is encoded in a sequence space of 20 300 10 390 : (A " sequence space " being the number of possible sequences of a particular length). It appears that no DNA library can be made large(More)
In vitro DNA-based predator-prey system with oscillatory kinetics. [6] Junghuei Chen and David Harlan Wood. A new DNA separation technique with low error rate. In Rubin and Wood [37], pages 43–56. [7] Junghuei Chen and David Harlan Wood. The role of high-fidelity separation in DNA computing .
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