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Findings from molecular genetic studies and analyses of postmortem and peripheral tissue led to the hypothesis that neurotrophins-as crucial moderators of neuroplasticity-impact on the pathophysiology of autism spectrum disorder (ASD). The study projects aimed to complement former results on the role of brain-derived neurotrophic factor (BDNF), a member of(More)
The controlled-substance analog N-monomethyl-1-(4-methoxyphenyl)-2-aminopropane (PMMA) may be viewed as being either the 4-methoxy analog of methamphetamine or the N-methyl analog of 1-(4-methoxyphenyl)-2-aminopropane (PMA). Because of its abuse potential, PMMA was examined with regard to (a) its stimulus properties in rats trained to discriminate either(More)
Changes in plasma corticosterone (CCS) levels following intraperitoneal injections of nicotine were measured in four inbred mouse strains: DBA/2Ibg, C57BL/6Ibg, C3H/2Ibg, and A/J. In all four strains, nicotine produced a dose-dependent (0.5-2.0 mg/kg nicotine) increase in plasma CCS levels which peaked 10-30 min after injection. Saline increased plasma CCS(More)
Liver protein synthesis involves a complex series of reactions which is influenced by hormones, nutritional state and general health of an animal. The secretory processes for proteins, such as albumin, also interact with the protein synthetic machinery of the liver. Alcohol may affect synthesis and/or secretion at a number of loci and the mechanism of(More)
Acute exposure to nicotine produces an elevation of plasma corticosterone levels in rodents. The consequences of repeated exposure to nicotine administered intraperitoneally (IP) were examined in three inbred strains of mice, DBA/2Ibg, C3H/2Ibg and A/J. These strains of mice have been shown previously to differ in a variety of behavioral and physiological(More)
Differences in resistance to 3-mercaptopropionic acid (MP)-induced seizures exist between DBA/2Ibg and C57BL/6Ibg inbred strains of mice; C57BL/6Ibg mice are more resistant to MP-induced seizures. To determine the mode of inheritance for seizure resistance, a classical genetic analysis was conducted using these two parental strains, their F1, F2, and(More)
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