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Biozzi mice: of mice and human neurological diseases.

• Sandra Amor, Paul A. Smith, Bert A. 't Hart, David Baker
• Journal of neuroimmunology
• 2005

In 1972 Guido Biozzi selectively bred mice to study the immunopathological mechanisms underlying polygenic diseases. One line, the Biozzi antibody high (AB/H) mouse (now designated the ABH strain)… (More)

Unravelling the T-cell-mediated autoimmune attack on CNS myelin in a new primate EAE model induced with MOG34-56 peptide in incomplete adjuvant.

• S Anwar Jagessar, Nicole Heijmans, +7 authors Bert A. 't Hart
• European journal of immunology
• 2012

Induction of experimental autoimmune encephalomyelitis (EAE) has been documented in common marmosets using peptide 34-56 from human myelin/oligodendrocyte glycoprotein (MOG(34-56) ) in incomplete… (More)

Animal models for arthritis: innovative tools for prevention and treatment.

• George E Kollias, Piyi Papadaki, +20 authors Steffen Gay
• Annals of the rheumatic diseases
• 2011

The development of novel treatments for rheumatoid arthritis (RA) requires the interplay between clinical observations and studies in animal models. Given the complex molecular pathogenesis and… (More)

Prospects of immunotherapy for rheumatoid arthritis

• Bert A. 't Hart, Henny G. Otten
• Pharmacy World and Science
• 1993

The main challenge in the development of new modalities for the treatment of rheumatoid arthritis is to enhance the specificity while reducing the adverse side-effects of therapeutics. Biotechnology… (More)

Autoimmune Encephalomyelitis against Acute Fatal Experimental Costimulation Protects Rhesus Monkeys Selective Blockade of CD28-Mediated T Cell

• Bert A. 't Hart, Bernard Vanhove, +8 authors Bert A. ’t Hart
• 2015

CD40 in Clinical Inflammation: From Multiple Sclerosis to Atherosclerosis

• Jon D Laman, Mark G. J. de Boer, Bert A. 't Hart
• Developmental immunology
• 1998

The interactions of CD40 and CD40L have been known for some time to critically regulate B-cell responses with respect to proliferation, isotype switching, antibody production, and memory formation.… (More)

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