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- François Ghiringhelli, Lionel Apetoh, +23 authors Laurence Zitvogel
- Nature Medicine
- 2009
The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs), which present antigens from dying cancer cells to prime tumor-specific interferon-γ (IFN-γ)–producing T… (More)
Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors.
- Eilon D. Kirson, VladimÃr Dbalý, +13 authors Yoram Palti
- Proceedings of the National Academy of Sciences…
- 2007
We have recently shown that low intensity, intermediate frequency, electric fields inhibit by an anti-microtubule mechanism of action, cancerous cell growth in vitro. Using implanted electrodes,… (More)
- Silvia Schnyder-Candrian, Dieudonnée Togbé, +6 authors Bruno Schnyder
- The Journal of experimental medicine
- 2006
T helper (Th)17 cells producing interleukin (IL)-17 play a role in autoimmune and allergic inflammation. Here, we show that IL-23 induces IL-17 in the lung and IL-17 is required during antigen… (More)
- Fanny Chalmin, Grégoire Mignot, +15 authors François Ghiringhelli
- Immunity
- 2012
Although Th17 cells are known to promote tissue inflammation and autoimmunity, their role during cancer progression remains elusive. Here, we showed that in vitro Th17 cells generated with the… (More)
- Fanny Chalmin, Sylvain Ladoire, +20 authors François Ghiringhelli
- The Journal of clinical investigation
- 2010
Myeloid-derived suppressor cells (MDSCs) have been identified in humans and mice as a population of immature myeloid cells with the ability to suppress T cell activation. They accumulate in… (More)
- Sophie Viaud, Fabiana Saccheri, +30 authors Laurence Zitvogel
- Science
- 2013
Cyclophosphamide is one of several clinically important cancer drugs whose therapeutic efficacy is due in part to their ability to stimulate antitumor immune responses. Studying mouse models, we… (More)
- Christophe Paget, Thierry Mallevaey, +9 authors François Trottein
- Immunity
- 2007
Invariant natural killer T (iNKT) cells are a subset of innate lymphocytes that recognize lipid antigens in the context of CD1d and mediate potent immune regulatory functions via the rapid production… (More)
- Christophe Borg, Abdelali Jalil, +10 authors Laurence Zitvogel
- Blood
- 2004
Mature dendritic cells (mDCs) can trigger the effector functions of natural killer (NK) cells. Knock-out, small-interfering RNA or neutralizing antibodies targeting interleukin 12 (IL-12) subunits… (More)
Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis.
- Paméla Gasse, Nicolas Riteau, +8 authors Isabelle Couillin
- American journal of respiratory and critical care…
- 2009
RATIONALE
Lung injury leads to pulmonary inflammation and fibrosis through myeloid differentiation primary response gene 88 (MyD88) and the IL-1 receptor 1 (IL-1R1) signaling pathway. The molecular… (More)
- Nicolas Riteau, Paméla Gasse, +9 authors Isabelle Couillin
- American journal of respiratory and critical care…
- 2010
RATIONALE
Pulmonary fibrosis is a devastating as yet untreatable disease. We previously investigated the endogenous mediators released on lung injury and showed that uric acid is a danger signal… (More)