Bernhard Miller

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Although regulation of voltage-dependent calcium current (ICa,V) by neurotransmitters is a ubiquitous mechanism among nerve cells, the signaling pathways involved are not well understood. We have determined previously that in a neuroblastoma-glioma hybrid cell line (NG108-15), the heterotrimeric G-protein G13 mediates the inhibition of ICa,V produced by(More)
The present work aimed to proof the functionality of the non-mevalonate pathway in cyanobacteria. It was intended to isolate the 1-deoxy-D-xylulose 5-phosphate (DXP) reductoisomerase gene (dxr), as this gene encodes the enzyme which catalyzes a pathway-specific, indicative step of this pathway. For this purpose, a segment of dxr was amplified from(More)
Experiments have been performed to prove the existence and the functionality of the novel mevalonate independent 1-deoxyxylulose 5-phosphate isoprenoid biosynthesis pathway in cyanobacteria. For this purpose, a segment of the 1-deoxyxylulose 5-phosphate synthase gene (dxs) was amplified from Synechococcus leopoliensis SAUG 1402-1 DNA via PCR using(More)
3,4-Diarylpyrrole-2,5-dicarboxylic acids are suitable starting materials for the biomimetic synthesis of several types of marine pyrrole alkaloids, e. g. lamellarins [2], polycitrins [3], polycitones [4], and storniamides [5]. Several of these compounds exhibit interesting anticancer activities [6], and even the simple pyrrole dicarboxylic acids 1 and 2,(More)
Replacement of one of the chloride leaving groups in trans-[PtCl2(NH3)(L)] by the nucleobase 9-ethylguanine gives the nucleobase cations [SP-4-2]-[PtCl(9-ethylguanine)(NH3)(L)]+ (L=NH3, 1; L=quinoline, 3), which are models for the monofunctional adduct on DNA. Displacement of Cl– in 1 and 3 by either 5'-guanosine monophosphate (5'-GMP) or(More)
When it comes to security risks, especially malware, Mac OS X has the questionable reputation of being inherently safe. While there is a substantial body of research and implementations dealing with malware on Windows and, more recently, Android systems, Mac OS X has received little attention so far. To amend this shortcoming, we built a Mac OS X based(More)
The concept of the niche party has become increasingly popular in analyses of party competition. Yet, existing approaches vary in their definitions and their measurement approaches. We propose using a minimal definition that allows us to compare political parties in terms of their 'nicheness'. We argue that the conceptual core of the niche party concept is(More)