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BACKGROUND The pleasant effects of food and alcohol intake are partially mediated by mu-opiate receptors in the ventral striatum, a central area of the brain reward system. Blockade of mu-opiate receptors with naltrexone reduces the relapse risk among some but not all alcoholic individuals. OBJECTIVE To test the hypothesis that alcohol craving is(More)
To assess the ability of [(18)F]fluorodeoxyglucose positron emission tomography for the early prediction of response in patients with relapsed metastatic germ cell tumours undergoing salvage high-dose chemotherapy. The role of positron emission tomography was compared with established means of tumour response assessment such as CT scans/MRI and serum tumour(More)
Due to the stochastic nature of radioactive decay, any measurement of radioactivity concentration requires spatial averaging. In pharmacokinetic analysis of time-activity curves (TAC), such averaging over heterogeneous tissues may introduce a systematic error (heterogeneity error) but may also improve the accuracy and precision of parameter estimation. In(More)
Purpose: The purpose of this study was to assess the ability of fluorine-18-labeled fluorodeoxyglucose positron emission tomography (18 F-FDG-PET), computed tomography (CT)/magnetic resonance imaging (MRI) and serum tumor marker (TM) to predict the viability of residual masses after high-dose chemotherapy (HD-Ctx) in patients with metastatic germ-cell(More)
Even though high-dose chemotherapy followed by autologous stem cell support has proven superior to conventional treatment, 1 relapse occurs in approximately 75% of patients within five years after autologous trans-plantation. 2 Initiating salvage treatment after high-dose therapy may be a reasonnable approach with survival time from relapse being more than(More)
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