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Metabolism: A Bottleneck in In Vitro Toxicological Test Development
This is the 54th report of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). The main objective of ECVAM, as defined in 1993 by its ScientificExpand
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Studies comparing in vivo:in vitro metabolism of three pharmaceutical compounds in rat, dog, monkey, and human using cryopreserved hepatocytes, microsomes, and collagen gel immobilized hepatocyte
The in vivo metabolism of three pharmaceutical compounds, EMD68843, EMD96785, and EMD128130, was compared in fresh and cryopreserved hepatocyte (CPH) suspensions and microsomes from rat, dog, monkey,Expand
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Influence of asimadoline, a new kappa-opioid receptor agonist, on tubular water absorption and vasopressin secretion in man.
AIMS The purpose of the study was to investigate the effects of asimadoline, a new kappa-opioid agonist, on renal function and on hormones related to body fluid balance as well as its tolerability inExpand
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In Vitro Characterization of Sarizotan Metabolism: Hepatic Clearance, Identification and Characterization of Metabolites, Drug-Metabolizing Enzyme Identification, and Evaluation of Cytochrome P450
In vitro biotransformation studies of sarizotan using human liver microsomes (HLM) showed aromatic and aliphatic monohydroxylation and dealkylation. Recombinant cytochromes P450 (P450) together withExpand
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Enteral exsorption of acetaminophen after intravenous injection in rats: influence of activated charcoal on this clearance path.
  • F. Eyer, N. Jung, +6 authors T. Zilker
  • Chemistry, Medicine
  • Basic & clinical pharmacology & toxicology
  • 1 September 2007
The fate of acetaminophen after intravenous injection in whole bowel-irrigated rats (n = 40) and the influence of activated charcoal on the kinetics were investigated. After randomization to fourExpand
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3.9. Toxicokinetics and Metabolism
Among the key provisions of the 7th Amendment to the EU Cosmetics Directive, it is stipulated that the European Commission should provide an estimated timetable for the provision of alternativeExpand
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Establishment of a novel in vitro system for studying the interaction of xenobiotic metabolism of liver and intestinal microflora
Abstract. We developed a new two-chamber system for the coculture of hepatocytes and fecal microflora under aerobic and anaerobic conditions, respectively, to investigate the sequential metabolism ofExpand
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4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridines: potent arylacetic acid-derived AT1 antagonists with improved affinity for the AT2 receptor
The replacement of dimethylacetamide with arylacetic acid esters and acetamides at the imidazo[4,5-c]pyridine 5-position of EMD 66684 2 imparts affinity for the AT2 receptor. The highest affinity wasExpand
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