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- Bernhard Klingenberg, Alan Agresti
- Biometrics
- 2006

This article considers global tests of differences between paired vectors of binomial probabilities, based on data from two dependent multivariate binary samples. Difference is defined as either an inhomogeneity in the marginal distributions or asymmetry in the joint distribution. For detecting the first type of difference, we propose a multivariate… (More)

In magazine advertisements for new drugs, it is common to see summary tables that compare the relative frequency of several side effects for the drug and for a placebo, based on results from placebo-controlled clinical trials. This paper summarizes ways to conduct a global test of equality of the population proportions for the drug and the vector of… (More)

- Olle Bälter, Emma Enström, Bernhard Klingenberg
- Computers & Education
- 2013

- Bernhard Klingenberg
- Statistics in medicine
- 2009

This article suggests a unified framework for testing Proof of Concept (PoC) and estimating a target dose for the benefit of a more comprehensive, robust and powerful analysis in phase II or similar clinical trials. From a pre-specified set of candidate models, we choose the ones that best describe the observed dose-response. To decide which models, if any,… (More)

- Bernhard Klingenberg, Aldo Solari, Laura Salmaso, Fortunato Pesarin
- Biometrics
- 2009

SUMMARY
Many assessment instruments used in the evaluation of toxicity, safety, pain, or disease progression consider multiple ordinal endpoints to fully capture the presence and severity of treatment effects. Contingency tables underlying these correlated responses are often sparse and imbalanced, rendering asymptotic results unreliable or model fitting… (More)

- Amanda D. Rice, Leslie B. Wakefield, +5 authors Lawrence J. Wurn
- Healthcare
- 2014

A validated questionnaire to assess the impact of small bowel obstructions (SBO) on patients' quality of life was developed and validated. The questionnaire included measurements for the impact on the patients' quality of life in respect to diet, pain, gastrointestinal symptoms and daily life. The questionnaire was validated using 149 normal subjects.… (More)

- Bernhard Klingenberg
- Computational Statistics & Data Analysis
- 2008

Time series of discrete random variables present unique statistical challenges due to serial correlation and uneven sampling intervals. While regression models for a series of counts are well developed, only few methods are discussed for the analysis of moderate to long (e.g. from 20 to 152 observations) binary or binomial time series. This article suggests… (More)

- Bernhard Klingenberg
- Statistics in medicine
- 2014

Writing the variance of the Mantel-Haenszel estimator under the null of homogeneity and inverting the corresponding test, we arrive at an improved confidence interval for the common risk difference in stratified 2 × 2 tables. This interval outperforms a variety of other intervals currently recommended in the literature and implemented in software. We also… (More)

- Bernhard Klingenberg, Ville Satopaa
- Computational Statistics & Data Analysis
- 2013

When modeling a dose-response for a drug based on bivariate binary data such as two co-primary efficacy endpoints in early stages of development, there is usually uncertainty about the from of the true underlying dose-response shape. Often, investigators fit several different models that are deemed plausible, but later fail to acknowledge this uncertainty… (More)