We evaluate predictive regressions that explicitly consider the time-variation of coefficients in a comprehensive Bayesian framework. This allows for fast and consistent adjustment of regression coefficients to changes in the underlying economic relationships (e.g., changes in the regulatory environment) as we document explicitly for the coefficient of the… (More)
Let M be a closed enlargeable spin manifold. We show non-triviality of the universal index obstruction in the K-theory of the maximal C *-algebra of the fundamental group of M. Our proof is independent from the injectivity of the Baum-Connes assembly map for π 1 (M) and relies on the construction of a certain infinite dimensional flat vector bundle out of a… (More)
Using methods from coarse topology we show that fundamental classes of closed en-largeable manifolds map non-trivially both to the rational homology of their fundamental groups and to the K-theory of the corresponding reduced C *-algebras. Our proofs do not depend on the Baum– Connes conjecture and provide independent confirmation for specific predictions… (More)
We describe an explicit chain map from the standard resolution to the minimal resolution for the finite cyclic group Z k of order k. We then demonstrate how such a chain map induces a " Z k-combinatorial Stokes theorem " , which in turn implies " Dold's theorem " that there is no equivariant map from an n-connected to an n-dimensional free Z k-complex. Thus… (More)
We give explicit examples of degree 3 cohomology classes not Poincaré dual to submanifolds, and discuss the real-isability of homology classes by submanifolds with Spin c normal bundles.
We prove that many simply connected symplectic four-manifolds dissolve after connected sum with only one copy of S 2 × S 2. For any finite group G that acts freely on the three-sphere we construct closed smooth four-manifolds with fundamental group G which do not admit metrics of positive scalar curvature, but whose universal covers do admit such metrics.
Connective tissue turnover plays a prominent role in tumour growth and metastasis. We followed serum levels of seven connective tissue parameters in 37 patients with colorectal cancer metastatic to the liver prior to and during chemotherapy. Serum samples with episodes of tumour control (n=112) showed an increase of matrix metalloproteinase-2 (MMP-2)… (More)
The presence of an 11 beta-hydroxyl group is essential for the anti-inflammatory and immunosuppressive effects of glucocorticoids. Interconversion of the 11 beta-hydroxyl into the corresponding 11 beta-keto group and vice versa by 11 beta-hydroxysteroid-dehydrogenase (11 beta-HSD) may thus play a pivotal role in the efficacy of these steroids. Therefore, we… (More)