Bernhard Brune

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The toxic reactive aldehyde lipid peroxidation byproduct 4-hydroxy-2-nonenal (HNE) is thought to be a major contributor to oxidant stress-mediated cell injury. HNE induced apoptosis in RAW 264.7 murine macrophage cells in a dose-dependent manner within 6-8 h after exposure. Expression of the antiapoptotic protein Bcl-2 in stably transfected RAW 264.7 cells(More)
The sphingolipid sphingosine-1-phosphate (S1P) is an important regulator of immune cell functions in vivo. Besides recruiting lymphocytes to blood and lymph, it may promote immune cell survival and proliferation, but also interferes with their activation. Hereby, S1P may act as an intracellular second messenger or cofactor or, upon being secreted from(More)
Aims In previous studies we could show that male neonates with a Body Mass Index (BMI) <10P have a double risk to develop obesity during the first 6 years of life compared to females. As the main factor of influence for developing obesity we could identify the maternal BMI for both male and female infants. This leads to the hypothesis that maternal(More)
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