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Tissue factor and tumor: clinical and laboratory aspects.
This review summarizes data demonstrating the role of TF in tumor development, metastasis and angiogenesis. TF is a transmembrane protein that is expressed constitutively in some kinds ofExpand
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Antisense-mediated hTERT inhibition specifically reduces the growth of human bladder cancer cells.
PURPOSE The expression of human telomerase reverse transcriptase (hTERT) is associated with cellular aging and tumorigenesis. It was found in nearly all cancer types but not in most normal, somaticExpand
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Efficient improvement of hammerhead ribozyme mediated cleavage of long substrates by oligonucleotide facilitators.
Hammerhead ribozymes were found to be not very efficient in cleaving long RNA substrates in trans. Oligonucleotide facilitators, capable of affecting hammerhead ribozymes by interacting with theExpand
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Oligonucleotide facilitators may inhibit or activate a hammerhead ribozyme.
Facilitators are oligonucleotides capable of affecting hammerhead ribozyme activity by interacting with the substrate at the termini of the ribozyme. Facilitator effects were determined in vitroExpand
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Biological nano-functionalization of titanium-based biomaterial surfaces: a flexible toolbox
Surface functionalization with bioactive molecules (BAMs) on a nanometre scale is a main field in current biomaterial research. The immobilization of a vast number of substances and molecules,Expand
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Tissue specific expression and serum levels of human tissue factor in patients with urological cancer.
Human tissue factor (TF) is involved in tumor angiogenesis and metastasis. However, little is known about the distribution of TF in urological cancer. In this study we investigated the TF expressionExpand
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Antisense-mediated inhibition of survivin, hTERT and VEGF in bladder cancer cells in vitro and in vivo.
Since cancer cells are characterised by multiple genetic alterations the single inhibition of one tumour- associated gene might not be sufficient as a therapeutic strategy. We examined the effects ofExpand
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Experimental hypoxia is a potent stimulus for radiotracer uptake in vitro: comparison of different tumor cells and primary endothelial cells.
Hypoxia causes upregulation of vascular endothelial growth factor (VEGF) which is a key regulator in tumor angiogenesis and essential for the proliferation of endothelial cells. Endothelial cellsExpand
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Are overexpressed alternative survivin transcripts in human bladder cancer suitable targets for siRNA-mediated in vitro inhibition?
In order to reduce side effects of survivin-inhibiting anticancer therapies, we determined the expression of the survivin transcripts survivin-wild-type (survivin-wt), survivin-DeltaEx3 (DeltaEx3)Expand
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Oligonucleotide facilitators enable a hammerhead ribozyme to cleave long RNA substrates with multiple-turnover activity.
Trans-acting hammerhead ribozymes are usually efficient in cleaving short RNA model substrates under both single-turnover and multiple-turnover conditions. In contrast, when long RNAs are theExpand
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