except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use of general descriptive names, trade names, trademarks, etc., in this… (More)
The region-specific homeotic gene spalt (sal) of Drosophila specifies head and tail as opposed to trunk segments. During later stages of ontogenesis, sal is also expressed and required in a small number of tissues and organs in the developing embryo. sal encodes a zinc finger protein of unusual but characteristic structure. We made use of these unique… (More)
As every mathematics text, this text can be read linearly, cover-to-cover. This approach however would delay readers that are interested in the content of latter chapters. As it turns out, such delay is not necessary. The concept map below indicates how content can be organized to satisfy a variety of interests. The only common requirement is satisfactory… (More)
Regulated intramembrane proteolysis is a central cellular process involved in signal transduction and membrane protein turnover. The presenilin homologue signal-peptide-peptidase-like 2a (SPPL2a) has been implicated in the cleavage of type 2 transmembrane proteins. We show that the invariant chain (li, CD74) of the major histocompatability class II complex… (More)
An ordered set P has the fixed point property iff every order-preserving self-map of P has a fixed point. This paper traces the chronological development of research on this property, including most recent developments and open questions.
Regulated intramembrane proteolysis is of pivotal importance in a diverse set of developmental and physiological processes. Altered intramembrane substrate turnover may be associated with neurodegeneration, cancer and impaired immune function. In this review we will focus on the intramembrane proteases which have been localized in the lysosomal membrane.… (More)
For the lexicographic product G • H of two graphs G and H so that G is connected, we prove that if the copnumber c(G) of G is greater than or equal to 2, then c(G • H) = c(G). Moreover, if c(G) = c(H) = 1, then c(G • H) = 1. If c(G) = 1, G has more than one vertex, and c(H) ≥ 2, then c(G • H) = 2. We also provide the copnumber for general lexicographic… (More)