Bernd Rosenhammer

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Mutations in the myocilin gene (MYOC) are causative for 10% of cases with juvenile open-angle glaucoma and 3-4% of those with primary open-angle glaucoma. Myocilin is a secreted protein with relatively ill-defined matricellular properties. Despite its high expression in the eye, myocilin-deficient mice have originally been reported to have no obvious ocular(More)
Olfactomedin 1 (OLFM1) is a secreted glycoprotein and member of the olfactomedin protein family, which is preferentially expressed in various areas throughout the central nervous system. To learn about the functional properties of OLFM1 in the eye, we investigated its localization in the mouse and pig eye. In addition, we analyzed the ocular phenotype of(More)
Die Sarkoidose ist eine Systemerkrankung unklarer Ätiologie, die durch das Auftreten nichtverkäsender Granulome in den betroffenen Organen charakterisiert ist. Anfangs tritt die Erkrankung nicht selten durch Hautveränderungen in Erscheinung und zeigt dabei klinisch ein heterogenes Bild. Wir berichten im Folgenden über eine 66-jährige Patientin, die sich mit(More)
1. Nemazee DA, Burki K (1989) Clonal deletion of B lymphocytes in a transgenic mouse bearing antiMHC class I antibody genes. Nature 337:562–566 2. Goodnow CC, Crosbie J, Adelstein S et al (1988) Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334:676–682 3. Gay D, Saunders T, Camper S,(More)
Advanced Peyronie’s disease (PD) with severe penile deviation demands grafting procedures following plaque incision or partial plaque excision in order to avoid penile shortening and to improve quality of life of affected patients. Small intestinal submucosa (SIS) is an established xenograft. The objective of the present study was to validate external(More)
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