Bernd Möller

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The current preferred treatment for patients with hepatitis C virus (HCV) is combination therapy consisting of pegylated interferon alfa and ribavirin (RBV) for 24-48 weeks. Although this approach appears to be highly effective for patients with HCV genotypes 2 or 3, who have a sustained virological response (SVR) of approximately 80%, the treatment(More)
The combination treatment of peginterferon alpha-2a (PEG-IFN alpha-2a; Pegasys) plus ribavirin (RBV) is recommended as a standard care for HCV infections. Side effects and aspects of efficacy and safety have to be balanced. This study evaluates clinical practice data on safety and efficacy of HCV treatment with PEG-IFN in combination with RBV over 24 and 48(More)
According to published data, 60% of hepatitis C virus (HCV)-infected patients in Croatia have HCV genotype 1. The second most common genotype is 3a (36%). Standard treatment regimen for patients with chronic hepatitis C is a combination of pegylated interferon alfa (2a or 2b) with ribavirin, in duration guided by genotype: patients with genotype 1 are(More)
In the paper a new concept of modeling uncertainty is presented, based on the theory of fuzzy random variables. By this means, a super-ordinate uncertainty model is made available which includes the models developed so far, based on random variables and fuzzy variables as special cases. The fuzzy random variables are accounted for as input values in the(More)
UNLABELLED Although sofosbuvir has been approved for patients with genotypes 2/3 (G2/3), many parts of the world still consider pegylated Interferon alpha (P) and ribavirin (R) as standard of care for G2/3. Patients with rapid virological response (RVR) show response rates >80%. However, SVR (sustained virological response) in non-RVR patients is not(More)
  • Henrik Lund, Frede Hvelplund, Poul Alberg Østergaard, Bernd Möller, Brian Vad Mathiesen, Poul Erik Morthorst +6 others
  • 2010
Acknowledgement This study is part of the research project Coherent Energy and Environmental System Analysis (CEESA), partly financed by the Danish Council for Strategic Research. The rest has been financed by the companies and institutions of the authors. This study has been initiated and conducted solely on the initiative of the authors and involve no(More)
In this paper mathematical methods for prediction of uncertain structural responses with the aid of fuzzy time series are presented. Uncertain measurments of structural loads and responses respectively at equally spaced discrete time points are modeled as fuzzy variables. Hence uncertain measurments over time are considered as time series with fuzzy data.(More)
Open textile structures made of AR glass filament yarns are finding increasing application in civil engineering, e.g. as reinforcement in thin concrete strengthening layers. A knowledge of material parameters is a precondition for the application of such materials. In this paper, experimental and numerical investigations aimed at collecting information on(More)