Bernd Jülicher

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A multi-residue high-performance liquid chromatography (HPLC) method with photodiode-array detection is presented for the determination of 12 non-steroidal anti-inflammatory drugs (NSAIDs) in plasma. This method has been validated under the consideration of actual alpha- and beta-errors according to an in-house validation concept based on a fractional(More)
The recently presented in-house validation concept developed on the basis of a variance component model is extended and optimised by basing it on a fractional factorial sampling scheme. The presented approach relies on a comprehensive mathematical model to assess simultaneously the in-house reproducibility and its components in addition to(More)
This report presents the results of an investigation on the accumulation of beta-agonist residues in the retinal tissue of food producing animals. Three different species, calf, pig and turkey, were treated with six different beta-agonists and analysed for beta-agonist residues in retinal tissue applying a newly developed retina preparation procedure which(More)
This article presents the results of a comparative study of nine commercially available ELISA test kits for clenbuterol and other beta 2-agonists currently being used in veterinary drug residue control of live and slaughtered animals in the European Union (EU). By determining measuring ranges, B/B0-50% values, inter- and intra-assay variations and(More)
Two Beta-Agonist Interlaboratory Studies, 5/96 and 11/97, were designed and evaluated according to the International Harmonised Protocol for the Proficiency Testing of (Chemical) Analytical Laboratories (ISO/REMCO N 280) jointly elaborated by ISO, IUPAC and AOAC. In the sense of proficiency testing, interlaboratory studies are part of external quality(More)
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