Bernd Hofmann

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The avermectins ivermectin and doramectin and the milbemycins milbemycin A4 oxime and moxidectin were tested for filaricidal activity in Mastomys coucha infected with Litomosoides carinii, Acanthocheilonema viteae, Brugia malayi, and B. pahangi. Single subcutaneous doses of 0.005-5 mg/kg (L. carinii), 0.0005-0.5 mg/kg (A. viteae), 0.5 and 5 mg/kg (B.(More)
Gianotti-Crosti syndrome (GCS) is a distinct exanthematic, acrolocated eruption of childhood caused by a variety of infectious agents. Historically hepatitis B antigen positive (HBsAG+) papular acrodermatitis of childhood and HBsAg negative (HBsAg-) papulovesicular acrolocated syndrome have been distinguished. Here we characterize the spectrum of associated(More)
Correct pricing of options and other financial derivatives is of great importance to financial markets and one of the key subjects of mathematical finance. Usually, parameters specifying the underlying stochastic model are not directly observable, but have to be determined indirectly from observable quantities. The identification of local volatility(More)
In the analysis of ill-posed inverse problems the impact of solution smoothness on accuracy and convergence rates plays an important role. For linear illposed operator equations in Hilbert spaces and with focus on the linear regularization schema we will establish relations between the different kinds of measuring solution smoothness in a point-wise or(More)
The characterization of the local ill–posedness and the local degree of nonlinearity are of particular importance for the stable solution of nonlinear ill–posed problems. We present assertions concerning the interdependence between the illposedness of the nonlinear problem and its linearization. Moreover, we show that the concept of the degree of(More)
In this paper we deal with aspects of characterizing the ill-posedness of nonlinear inverse problems based on the discussion of speciic examples. In particular, a parameter identiication problem to a second order diierential equation and its ill-posed linear components are under consideration. A new approach to the classiication of ill-posedness degrees for(More)
The clinical efficacy and tolerability of the topical receptor-selective retinoid tazarotene in the treatment of congenital ichthyoses was investigated. Twelve consecutive patients with different forms of congenital ichthyosis were enrolled in an open, non-randomized, intraindividually controlled, half-side pilot study. Diagnoses were X-linked recessive(More)