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BACKGROUND Intratracheal pressure (Ptrach) should be the basis for analysis of lung mechanics. If measured at all, Ptrach is usually assessed by introducing a catheter into the trachea via the lumen of the endotracheal tube (ETT). The authors propose a computer-assisted method for calculating Ptrach on a point-by-point basis by subtracting the(More)
Since the adult respiratory distress syndrome (ARDS) lung is known to be inhomogeneous, one could expect an uneven distribution of expiratory time constant during uninterrupted mechanical ventilation. We investigated the time constant/volume relationship of passive expiration, and their modification by external resistive elements. In 12 paralysed intubated(More)
In patients mechanically ventilated for severe respiratory failure, respiratory system mechanics are non-linear, i.e., volume-dependent. We present a new computer-based multipoint method for simultaneously determining volume-dependent dynamic compliance and resistance. Our method is based on continuously determined tracheal pressure (Ptrach). Tidal volume(More)
The considerable additional ventilatory work needed to overcome the resistance of the endotracheal tube (ETT) is flow-dependent. In spontaneously breathing intubated patients this additional ventilatory work is therefore dependent on the flow pattern and cannot be adequately compensated for by support with a constant pressure. We propose a method to fully(More)
Computer aided patent portfolio analysis is a useful tool to evaluate both the R&D landscape and business opportunities. All necessary patent data can be generated from publicly accessible data bases. Patent data allow conclusions about a firm’s patent activity and the quality of its patent portfolio. Further, the international and technological scope of a(More)
Objective: To determine the tracheostomy tube-related additional work of breathing (WOBadd) in critically ill patients and to show its reduction by different ventilatory modes. Design: Prospective, clinical study. Setting: Medical ICU of a university teaching hospital. Intervention: Standard tracheostomy due to prolonged respiratory failure. Measurements(More)
Marketing and R&D strategies need to be aligned to increase the return from investment in new technologies. Various portfolio techniques have been widely used to support strategic planning. A new portfolio approach integrating market and technology portfolios to support market-oriented R&D planning is developed. The integrated portfolio is based on(More)
To compare the new mode of ventilatory Support, which we call automatic tube compensation (ATC), with inspiratory pressure support (IPS) with respect to pereeption of respiratory comfort. ATC unloads the resistance of the endotracheal tube (ETT) in inspiration by increasing the airway pressure, and in expiration by decreasing the airway pressure aecording(More)
BACKGROUND A step decrease in positive end-expiratory airway pressure (PEEP) is not followed by an instantaneous loss of the PEEP-induced increase in end-expiratory lung volume (EELV). Rather, the reduction of EELV is delayed, while adverse PEEP effects on hemodynamics are immediately attenuated upon the drop in airway pressure. Step PEEP increments were(More)