Bernat Soria

Abdelkrim Hmadcha9
Franz Martín4
Benoit R. Gauthier3
9Abdelkrim Hmadcha
4Franz Martín
3Benoit R. Gauthier
Learn More
  • Vincenzo Calvanese, Angelica Horrillo, Abdelkrim Hmadcha, Beatriz Suarez-Álvarez, Agustín F. Fernandez, Ester Lara +17 others
  • 2008
Developmental genes are silenced in embryonic stem cells by a bivalent histone-based chromatin mark. It has been proposed that this mark also confers a predisposition to aberrant DNA promoter hypermethylation of tumor suppressor genes (TSGs) in cancer. We report here that silencing of a significant proportion of these TSGs in human embryonic and adult stem(More)
Glucose homeostasis in blood is mainly maintained by insulin released from beta-cells and glucagon released from alpha-cells, both integrated within the pancreatic islet of Langerhans. The secretory processes in both types of cells are triggered by a rise in intracellular calcium concentration ([Ca2+](i)). In this study, rapid effects of the natural hormone(More)
  • Lourdes Acosta, Abdelkrim Hmadcha, Natalia Escacena, Inmaculada Pérez-Camacho, Antonio de la Cuesta, Rafael Ruiz-Salmeron +2 others
  • 2013
Stem cells have been successfully used for the treatment of critical limb ischemia (CLI). We conducted a clinical trial to determine the feasibility of using autologous adipose-derived mesenchymal stromal cells (AdMSCs) for the treatment of CLI. Unexpectedly, two diabetic patients developed peripheral microthrombosis. This adverse effect, which contrasts(More)
  • Christian Claude Lachaud, Daniela Pezzolla, Alejandro Domínguez-Rodríguez, Tarik Smani, Bernat Soria, Abdelkrim Hmadcha
  • 2013
In mammalian visceral organs, vascular smooth muscle cells (VSMCs) originate from an epithelial-to-mesenchymal transition (EMT) of embryonic mesothelial cells (MCs). The ability of adult MCs to recapitulate EMT and to acquire smooth muscle (SM) markers upon provasculogenic culture suggested they might retain embryonic vasculogenic differentiation potential.(More)
The field of pancreas development has markedly expanded over the last decade, significantly advancing our understanding of the molecular mechanisms that control pancreas organogenesis. This growth has been fueled, in part, by the need to generate new therapeutic approaches for the treatment of diabetes. The creation of sophisticated genetic tools in mice(More)
Mesenchymal stromal cells (MSCs) have been established as promising candidate sources of universal donor cells for cell therapy due to their contributions to tissue and organ homeostasis, repair, and support by self-renewal and multidifferentiation, as well as by their anti-inflammatory, antiproliferative, immunomodulatory, trophic, and proangiogenic(More)
  • Genoveva Berná, María Jesús Oliveras-López, Enrique Jurado-Ruíz, Juan Tejedo, Francisco Bedoya, Bernat Soria +1 other
  • 2014
Diabetes mellitus (DM) is considered a global pandemic, and the incidence of DM continues to grow worldwide. Nutrients and dietary patterns are central issues in the prevention, development and treatment of this disease. The pathogenesis of DM is not completely understood, but nutrient-gene interactions at different levels, genetic predisposition and(More)
Cell-attached and inside-out patch clamp recording was used to compare the functional expression of membrane ion channels in mouse and human embryonic stem cells (ESCs). Both ESCs express mechanosensitive Ca2+ permeant cation channels (MscCa) and large conductance (200 pS) Ca2+-sensitive K+ (BKCa2+) channels but with markedly different patch densities.(More)
Tissue-engineering technologies have progressed rapidly through last decades resulting in the manufacture of quite complex bioartificial tissues with potential use for human organ and tissue regeneration. The manufacture of avascular monolayered tissues such as simple squamous epithelia was initiated a few decades ago and is attracting increasing interest.(More)
  • Petra I. Lorenzo, Esther Fuente-Martín, Thierry Brun, Nadia Cobo-Vuilleumier, Carmen María Jimenez-Moreno, Irene G. Herrera Gomez +5 others
  • 2015
PAX4 is a key regulator of pancreatic islet development whilst in adult acute overexpression protects β-cells against stress-induced apoptosis and stimulates proliferation. Nonetheless, sustained PAX4 expression promotes β-cell dedifferentiation and hyperglycemia, mimicking β-cell failure in diabetic patients. Herein, we study mechanisms that allow(More)