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BACKGROUND Most analyses of age-related changes in fertility cannot separate effects due to reduced frequency of sexual intercourse from effects directly related to ageing. Information on intercourse collected daily through each menstrual cycle provides the data for estimating day-specific probabilities of pregnancy for specific days relative to ovulation,(More)
This multicentre study has produced a database of 7017 menstrual cycles contributed by 881 women. It provides improved knowledge on length and location of the " fertile window " (identified as of up to 12 days duration) and the pattern and level of daily conception probability. The day of ovulation was identified in each cycle from records of basal body(More)
BACKGROUND Intercourse results in a pregnancy essentially only if it occurs during the 6-day fertile interval ending on the day of ovulation. The strong association between timing of intercourse within this interval and the probability of conception typically is attributed to limited sperm and egg life times. METHODS A total of 782 women recruited from(More)
BACKGROUND The TwoDay Algorithm is a simple method for identifying the fertile window. It classifies a day as fertile if cervical secretions are present on that day or were present on the day before. This approach may be an effective alternative to the ovulation and symptothermal methods for populations and programmes that find current natural family(More)
Modulo " Simulazione molecolari di sistemi biologici " (INT. P02.001.001) " Protein and lipid interactions driving molecular mechanisms of in meso crystallization " " Identification of a new scaffold for Hsp90 C‐terminal inhibition " ACS Med. " Exploiting conformational dynamics in drug discovery: design of C‐terminal inhibitors of Hsp90 with improved(More)
CaMKII is a calcium and calmodulin-activated kinase that has been shown to regulate learning and memory in the brain, and contractility in blood vessels. Following Ca activation, CaMKII autophosphorylates, gaining a calcium-independent autonomous activity that reflects a molecular memory of having previously come into contact with calcium. The present study(More)
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