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  • Anne-Sophie Dugast, Thomas Haudebourg, +10 authors Bernard Vanhove
  • Biology, Medicine
  • Journal of immunology
  • 2008 (First Publication: 15 June 2008)
  • The immune tolerance to rat kidney allografts induced by a perioperative treatment with anti-CD28 Abs is associated with a severe unresponsiveness of peripheral blood cells to donor Ags. In thisContinue Reading
  • Nicolas Poirier, Agnes M Azimzadeh, +15 authors Bernard Vanhove
  • Biology, Medicine
  • Science translational medicine
  • 2010 (First Publication: 3 February 2010)
  • Transplantation is the treatment of choice for patients with end-stage organ failure. Its success is limited by side effects of immunosuppressive drugs, such as inhibitors of the calcineurin pathwayContinue Reading
  • Linda Scobie, Vered Padler-Karavani, +20 authors J Soulillou
  • Medicine, Biology
  • Journal of immunology
  • 2013 (First Publication: 15 September 2013)
  • Acellular materials of xenogenic origin are used worldwide as xenografts, and phase I trials of viable pig pancreatic islets are currently being performed. However, limited information is availableContinue Reading
  • Nicolas Poirier, Nahzli Dilek, +13 authors Gilles Blancho
  • Medicine
  • American journal of transplantation : official…
  • 2015
  • Selective targeting of CD28 might represent an effective immunomodulation strategy by preventing T cell costimulation, while favoring coinhibition since inhibitory signals transmitted through CTLA-4;Continue Reading
  • Nahzli Dilek, Nicolas Poirier, +7 authors Bernard Vanhove
  • Medicine, Biology
  • PloS one
  • 2013 (First Publication: 23 December 2013)
  • CD28, CTLA-4 and PD-L1, the three identified ligands for CD80/86, are pivotal positive and negative costimulatory molecules that, among other functions, control T cell motility and formation ofContinue Reading
  • Thomas Laumonier, Alexander J Walpen, +7 authors Robert Rieben
  • Biology, Medicine
  • Transplantation
  • 2003 (First Publication: 1 September 2003)
  • BACKGROUND The innate immune system, including complement and natural killer (NK) cells, plays a critical role in activation and damage of endothelial cells (ECs) during xenograft rejection. TheContinue Reading