Bernard Rousseau

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OBJECTIVE The objective was to assess the histological and viscoelastic shear tissue properties of the scarred vocal fold lamina propria at 2 and 6 months postoperatively in a canine model. STUDY DESIGN Experimental, nonrandomized prospective study. METHODS Six canine larynges were injured using a vocal fold stripping procedure. At 2 and 6 months(More)
Outcomes data after a surgical or behavioral intervention should be tracked until stability is reached. Often it is unclear how long patients should be followed and at what point an outcome can be considered stable. These issues have implications for treatment decision making, efficacy measurement, and the design of research studies. Vocal function data(More)
CONCLUSIONS Results of the current study revealed improved phonation threshold pressure (PTP), normalized mucosal wave amplitude (NMWA), and less contraction of the lamina propria in injured larynges treated with basic fibroblast growth factor (bFGF). OBJECTIVES We investigated the effects of local injection of bFGF for treatment of acute vocal fold(More)
OBJECTIVES The overarching goal of this line of research is to translate basic fibroblast growth factor (bFGF) treatment for vocal fold scarring into practical clinical use. In a previous canine investigation, we demonstrated that bFGF improves phonation threshold pressure, mucosal wave amplitude, and histologic measures in vocal folds treated after injury.(More)
OBJECTIVES To determine patient compliance with voice rest and the impact of voice rest on quality of life (QOL). STUDY DESIGN Prospective. SETTING University hospital. SUBJECTS AND METHODS Demographics, self-reported compliance, QOL impact on a 100-mm visual analog scale (VAS), and communication methods were collected from 84 participants from 2(More)
SUMMARY Phytochemical constituents of medicinal plants demonstrate inhibition of tissue and bacterial hyaluronidase. Echinacoside is a caffeoyl conjugate of Echinacea with known anti-hyaluronidase properties. The purpose of this study was to investigate the wound healing effects of Echinacea on vocal fold wound healing and functional voice outcomes. Pig(More)
Vocal fold scarring remains a therapeutic challenge. Hepatocyte growth factor (HGF) has strong antifibrotic activity and has proved to have therapeutic potential in restoration of scar tissues such as liver cirrhosis and lung fibrosis. The present study aimed to clarify the effects of HGF injection into scarred vocal folds in a canine model. Canine vocal(More)
OBJECTIVES/HYPOTHESIS Vocal fold scarring disrupts the layer structure of the vocal fold lamina propria that is essential for optimal mucosal vibration. Prevention of vocal fold scarring remains challenging. Hepatocyte growth factor (HGF) has strong antifibrotic activity. The authors' previous studies have found that HGF stimulates hyaluronic acid(More)