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BACKGROUND The cause of fulminant hepatitis (FH) in children is unexplained in up to 50% of cases. We report parvovirus B19 as an agent associated with FH in children and compare clinical characteristics of these patients with those of age-matched patients with FH of other origin. METHODS 45 patients presented with FH. No cause was apparent in 21(More)
19 of 153 patients attending an early-synovitis clinic were shown to have been recently infected by the human parvovirus (HPV). 5 other patients had evidence of some other closely preceding infection. HPV-infected patients typically presented with symmetrical peripheral polyarthropathy of sudden onset and moderate severity. Usually there was some(More)
Surveillance of rubella in England and Wales has included immunoglobulin M testing of oral (crevicular) fluid from reported case-patients since 1994. The need for laboratory confirmation to monitor rubella elimination is emphasized by poor sensitivity (51%, 95% confidence interval 48.9%-54.0%) and specificity (55%, 95% confidence interval 53.7%-55.6%) of(More)
The serum parvovirus-like virus (SPLV) is a ubiquitous human virus that suppresses the growth of bone-marrow stem cells in vitro. Antibody to it (anti-SPLV) was found in 28 (97%) of 29 children and young adults with haemophilia treated with clotting-factor concentrates but in only 36% of those who had received multiple blood transfusions and in 20% of(More)