Bernard De Jonghe

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To determine whether ICU-acquired paresis (ICUAP) is an independent risk factor of prolonged weaning. Second study of a prospective cohort of 95 patients who were enrolled in an incidence and risk factor study of ICUAP. Three medical and two surgical ICUs in four hospitals. Ninety-five patients without pre-existing neuromuscular disease recovering from the(More)
Objective: To systematically review instruments for measuring the level and effectiveness of sedation in adult and pediatric ICU patients.¶Study identification: We searched MEDLINE, EMBASE, the Cochrane Library and reference lists of the relevant articles. We selected studies if the sedation instrument reported items related to consciousness and one or more(More)
Objective: To summarize the prospective clinical studies of neuromuscular abnormalities in intensive care unit (ICU) patients. Study identification and selection: Studies were identified through MEDLINE, EMBASE, references in primary and review articles, personal files, and contact with authors. Through duplicate independent review, we selected prospective(More)
Intensive insulin therapy reduces mortality in subgroups of intensive care unit (ICU) patients, and awareness of the importance of blood glucose level (BGL) control has increased among ICU physicians and nurses. The impact of insulin treatment strategies on mortality may be influenced by their efficacy in achieving the target BGL range. We assessed the(More)
Objective: To evaluate the accuracy of procalcitonin (PCT) in predicting bacterial infection in ICU medical and surgical patients.¶Setting: A 10-bed medical surgical unit.¶Design: PCT, C-reactive protein (CRP), interleukin 6 (IL-6) dosages were sampled in four groups of patients: septic shock patients (SS group), shock without infection (NSS group),(More)
Cytoreductive surgery followed by intraperitoneal chemohyperthermia (IPCH) is a promising treatment for patients with peritoneal carcinomatosis, a disease with dismal prognosis. We describe our preliminary experience with staged adjuvant laparoscopic IPCH after complete resection in patients with locally or regionally advanced colorectal or gastric cancer.(More)
Objective: To assess the prognosis of patients with acute ischemic stroke who require mechanical ventilation and to determine early factors influencing mortality. Design: Prospective observational study. Setting: Medical intensive care unit with a cerebrovascular emergency unit in a university-affiliated hospital. Patients: Fifty-eight consecutive patients(More)
Despite an overall correlation between the bispectral index of the EEG (BIS) and clinical sedation assessment, unexpectedly high BIS values can be observed at deep sedation levels. We assessed the frequency, interindividual variability and clinical impact of high BIS values during clinically deep sedation. Prospective observational study in two(More)
To characterize the perceived utilization of physical restraint (PR) in mechanically ventilated intensive care unit (ICU) patients and to identify clinical and structural factors influencing PR use. A questionnaire was personally handed to one intensivist in 130 ICUs in France then collected on-site 2 weeks later. The questionnaire was returned by 121 ICUs(More)
The pathogenesis of intensive care unit-acquired paresis (ICUAP), a frequent and severe complication of critical illness, is poorly understood. Since ICUAP has been associated with female gender in some studies, we hypothesized that hormonal dysfunction might contribute to ICUAP. To determine the relationship between hormonal status, ICUAP and mortality in(More)