Bernard C Dean

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A 59-year-old woman who had had Parkinsonism for 12 years was treated with orphenadrine and levodopa combined with a dopa carboxylase inhibitor. The initial response was good, but after several years' treatment her condition alternated between severe bradykinesia and incapacitating, violent chorea, interspersed with short periods of mobility. A new regimen(More)
Two hundred and ninety-nine patients requiring treatment for a sleep disturbance were recruited into a double-blind multi-centre trial by 47 doctors. Patients received either 1 mg flunitrazepam or 20 mg temazepam for from 7 to 14 days. Analysis of the results of assessment in 246 patients by doctors and patients indicated that flunitrazepam was(More)
A double-blind study was carried out in 312 patients seen by their general practitioner for a sleep disorder requiring hypnotic treatment to compare the efficacy and event profile of flunitrazepam and triazolam. Patients were allocated at random to receive a night-time dose of 1 mg flunitrazepam or 0.25 mg triazolam for a minimum of 7 and a maximum of 14(More)
In a double blind cross-over study in 40 patients with mild to moderate anxiety, clorazepate 15 mg at bedtime was as effective as diazepam on global rating and slightly superior on target symptom assessment. There was a significantly higher incidence and frequency of side effects during diazepam treatment. Occurrence of side effect related to plasma(More)
OBJECTIVE This study investigated inter-rater agreement (IRA) among EEG experts for the identification of electrographic seizures and periodic discharges (PDs) in continuous ICU EEG recordings. METHODS Eight board-certified EEG experts independently identified seizures and PDs in thirty 1-h EEG segments which were selected from ICU EEG recordings(More)
A double-blind, multi-centre study was carried out in general practice to compare the efficacy and tolerance of treatment with bromazepam and lorazepam in 671 patients with anxiety. Patients were treated at random with either bromazepam (3 to 9 mg per day) or lorazepam (1 to 3 mg per day) for periods up to 2 weeks. In the doctors' global assessment of(More)
OBJECTIVE Succinylated gelatin is widely used in the management of hypovolaemic conditions. Volplex((R)) is a new presentation of succinylated gelatin in a flexible, collapsible bag, which is sterilised at 121 degrees C. This study aimed to document the safety and tolerability of Volplex((R)), using Gelofusine((R)) as a control, in elective surgery. (More)
A study was carried out in 80 mild to moderately depressed patients seen in general practice to assess the relative effectiveness and tolerance of a single night-time dose compared with the usual divided daily dosage regimen of a chlordiazepoxide (5 mg)/amitriptyline (12.5 mg) combination. Patients were assigned at random to receive either 1 capsule 3-times(More)
A total of 617 patients diagnosed by their general practitioner, according to set criteria, as having premenstrual symptoms were treated in general practice for three menstrual cycles with either pyridoxine or placebo. Treatment was randomized and administered blind. In the 434 patients analyzed, an improvement was found in 7 of the 9 symptoms assessed for(More)
A study was carried out in general practice in 85 habitual barbiturate takers, many of whom had been using this hypnotic for over 30 years, to assess the clinical practicability and acceptance of barbiturate substitution with flurazepam. Each barbiturate capsule or tablet being taken by patients was replaced by 15 mg flurazepam, either immediately or by(More)