Bernard Blanchard

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Performance on a Morris water task was examined in young rats whose mothers consumed a liquid diet consisting of 35% ethanol-derived calories (EDC) during pregnancy. Offspring of pair-fed (0% EDC) and ad lib lab chow (LC) dams served as controls. Rats were required to find a platform submerged below the surface in a pool of opaque water. A trial ended when(More)
In vivo microdialysis was used to examine changes in nucleus accumbens and striatal dopamine, dihydrophenylacetic acid (DOPAC), and homovanillic acid (HVA) following acute administration of ethanol (0.0, 0.25, 0.5, 1.0, or 2.0 g/kg) in male and female Long-Evans rats. Following dialysis, rats were trained to bar-press for oral ethanol reinforcement. In(More)
Using in vivo microdialysis, ethanol-induced dopamine release in nucleus accumbens and striatum was examined in adult male and female Long-Evans rats exposed prenatally to ethanol and in controls. Following dialysis, ethanol intake was measured in an operant paradigm. Control rats showed increased dopamine release in nucleus accumbens and striatum in(More)
Sex differences in ethanol intake in rats suggest that there may be sex differences in brain dopamine systems believed to mediate ethanol's reinforcing properties. To test this hypothesis, we used in vivo microdialysis to examine changes in nucleus accumbens and striatal dopamine, DOPAC and HVA following acute administration of several doses of ethanol in(More)
Prenatal exposure to alcohol may impair gonadal and behavioral development in male rats, possibly via reduction of perinatal androgenization. We examined locomotor activity on postnatal day 18 (PND 18), which is not influenced by perinatal androgens and juvenile play and testicular development (testes weight), which are dependent on perinatal androgen(More)
We psychopharmacologically examined dopamine function in rats exposed to ethanol prenatally. Pregnant rats received liquid diets of 35% or 0% ethanol-derived calories (EDC), or ad lib lab chow (LC). Twenty-eight-day-old offspring received systemic doses of apomorphine chosen to stimulate predominantly presynaptic (0.02 or 0.1 mg/kg) or postsynaptic dopamine(More)
The effects of prenatal alcohol exposure on grooming, locomotion, and rearing in response to stress were examined in adult rats whose mothers consumed a liquid diet containing 35% ethanol-derived calories (EDC). Offspring of both pair-fed 0% EDC mothers and ad libitum chow-fed mothers were included as controls. In Experiment 1, females groomed more than(More)
Pharmacological agents can be teratogenic but they can also be valuable tools in behavioral teratology. In this paper we describe some considerations we believe to be important in the use of psychopharmacology to assess the neurological underpinnings of behavioral deficits resulting from teratogenic exposure. Pharmacological challenges of animals exposed in(More)
Behavioral responses to amphetamine were examined in 28- and 42-day-old rats whose mothers consumed a liquid diet consisting of 35% ethanol-derived calories (EDC) during pregnancy. Offspring of pair-fed (0% EDC) and ad lib chow (LC) dams were included as controls. Animals received 0.0, 0.5, 1.0, or 2.0 mg/kg/ml d-amphetamine prior to single 2-hr tests in(More)
A database that provides statistical summaries for the purpose of research, planning, and decision making must remain rich, functionally useful, and protected from fraudulent usage. Unless restrictions are placed on the types of queries and responses, protecting an individual's information in the database is impossible. Some effective inference control(More)