Bernadette Sewell

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OBJECTIVE To evaluate the effectiveness and cost utility of a universally provided early years parenting programme. DESIGN Multicentre randomised controlled trial with cost-effectiveness analysis. SETTING Early years centres in four deprived areas of South Wales. PARTICIPANTS Families with children aged between 2 and 4 years. 286 families were(More)
BACKGROUND Antibiotic-associated diarrhoea (AAD) occurs most commonly in older people admitted to hospital and within 12 weeks of exposure to broad-spectrum antibiotics. Although usually a mild and self-limiting illness, the 15-39% of cases caused by Clostridium difficile infection [C. difficile diarrhoea (CDD)] may result in severe diarrhoea and death.(More)
OBJECTIVE To assess the overall cost effectiveness of the NHS breast screening programme, based on findings of the Independent UK Panel on Breast Cancer Screening and taking into account the uncertainty of associated estimates of benefits, harms, and costs. DESIGN A life table model comparing data from two cohorts. SETTING United Kingdom's health(More)
INTRODUCTION A study was performed to assess the cost of a rapid molecular assay (PCR) for diagnosis of Clostridium difficile infection (CDI) and the impact of its routine use on patient length of stay (LOS) in comparison with cell culture cytotoxin neutralization assay (CCNA). METHODS From March 2011 to September 2011, Xpert(®) C. difficile (Cepheid,(More)
BACKGROUND An ageing population increases demand on health and social care. New approaches are needed to shift care from hospital to community and general practice. A predictive risk stratification tool (Prism) has been developed for general practice that estimates risk of an emergency hospital admission in the following year. We present a protocol for the(More)
Our laboratory has previously demonstrated that 1,25-dihydroxyvitamin D 3 (1,25[OH] 2 D 3 ) rapidly stimulated polyphosphoinositide (PI) hydrolysis, raised intracellular Ca 2 1 , and activated two Ca 2 1 -dependent protein kinase C (PKC) isoforms, PKCa and b II in the rat large intestine. We also showed that the direct addition of 1,25(OH) 2 D 3 to isolated(More)
BACKGROUND Most patients presenting with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in primary care are prescribed an antibiotic, which may not always be appropriate and may cause harm. C-reactive protein (CRP) is an acute-phase biomarker that can be rapidly measured at the point of care and may predict benefit from antibiotic(More)
Objective To assess the overall cost effectiveness of the NHS breast screening programme, based on findings of the Independent UK Panel on Breast Cancer Screening and taking into account the uncertainty of associated estimates of benefits, harms, and costs. Design A life table model comparing data from two cohorts. Setting United Kingdom’s health service.(More)
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