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  • Georgios Kosmidis, Milena Bellin, +6 authors Simona Casini
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 2015 (First Publication: 1 November 2015)
  • One limitation in using human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) for disease modeling and cardiac safety pharmacology is their immature functional phenotype compared with adultContinue Reading
  • Elisa Giacomelli, Milena Bellin, +4 authors Christine L Mummery
  • Biology, Medicine
  • Development
  • 2017 (First Publication: 15 March 2017)
  • Cardiomyocytes and endothelial cells in the heart are in close proximity and in constant dialogue. Endothelium regulates the size of the heart, supplies oxygen to the myocardium and secretes factorsContinue Reading
  • C A Glashan, Alexander F A Androulakis, +12 authors Katja Zeppenfeld
  • Medicine
  • European heart journal
  • 2018 (First Publication: 14 August 2018)
  • Aims Electroanatomical voltage mapping (EAVM) is an important diagnostic tool for fibrosis identification and risk stratification in non-ischaemic cardiomyopathy (NICM); currently, distinct cut-offsContinue Reading
  • Luca Sala, Berend J van Meer, +24 authors Christine L Mummery
  • Biology, Medicine
  • Circulation research
  • 2017 (First Publication: 27 December 2017)
  • Rationale: There are several methods to measure cardiomyocyte and muscle contraction, but these require customized hardware, expensive apparatus, and advanced informatics or can only be used inContinue Reading
  • Berend J van Meer, Luca Sala, Leon G. J. Tertoolen, Godfrey L. Smith, Francis L. Burton, Christine L Mummery
  • Biology, Medicine
  • Current protocols in human genetics
  • 2018 (First Publication: 1 October 2018)
  • Quantification of contraction is essential to the study of cardiac diseases, injury, and responses to drugs. While there are many techniques to assess contractility, most rely on costly, dedicatedContinue Reading
  • Tessa de Korte, Puspita A Katili, +9 authors Chris Denning
  • Biology, Medicine
  • Annual review of pharmacology and toxicology
  • 2019 (First Publication: 6 January 2020)
  • In recent decades, drug development costs have increased by approximately a hundredfold, and yet about 1 in 7 licensed drugs are withdrawn from the market, often due to cardiotoxicity. This reviewContinue Reading
  • N. Gaio, Cinzia Silvestri, Berend J van Meer, Sten Vollebregt, Christine L Mummery, Ronald Haentjens Dekker
  • Engineering
  • IEEE Sensors Journal
  • 2016 (First Publication: 15 December 2016)
  • Microelectrode arrays (MEAs) are widely used in biological application to locally stimulate and record the electrical activity of living cells. Here, a novel fabrication process for a carbon nanotubeContinue Reading