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Kernicterus is a bilirubin-induced encephalopathy in newborn. Its spectrum ranges from subtle extrapyramidal to acute encephalopathy and chronic posticteric sequelae. Current treatment of this serious problem is far from optimal. Taurine has been documented to have protective effects on neuronal cells against ischemia in vivo and in vitro. This study used(More)
Previous work has shown that taurine protected neurons against unconjugated bilirubin (UCB)-induced neurotoxicity by preventing cell apoptosis and maintaining intracellular Ca²⁺ homeostasis in primary neuron culture. This study investigates the neurotoxicity of hyperbilirubinemia and neuroprotection of taurine in a clinically relevant murine model in vivo.(More)
BACKGROUND Industrialization in the northwest provinces of the People's Republic of China is accelerating rapid increases in early life environmental exposures, yet no publications have assessed health care provider capacity to manage common hazards. METHODS To assess provider attitudes and beliefs regarding the environment in children's health, determine(More)
The main purpose of this study was to identify policy maker opinions and attitudes towards children's environmental health (CEH), potential barriers to child-specific protective legislation and implementation in northwest China, and evaluate knowledge and attitudes about CEH before and after an educational conference. We conducted seventy-two interviews(More)
OBJECTIVE To investigate the genetic polymorphism of ADH3 and ALDH2 among Tibetan population in Qinghai and its relationship with drinking behavior. METHODS Polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP ) technique was used to detect the genotype of ADH3 and ALDH2. Drinking behavior was obtained by questionnaire. RESULTS(More)
The aim of this study is to identify the role of Tet1-mediated DNA demethylation in the neurotoxicity caused by unconjugated bilirubin (UCB) in vitro. Primary neuronal cells after cultured for 72 h were exposed to UCB (0-100 μmol/L) for 24 h. Following exposure to UCB cytotoxicity was determined with the methyl tetrazolium (MTT) assay, reactive oxygen(More)
OBJECTIVE In order to explore the effect of genetic polymorphism of CYP450 2El among the Tibetan population in Qinghai and its relationship to drinking behavior. METHODS By the self-reported questionnaires of 325 Tibetan male who contain 193 drinkers and 132 non-drinkers, we analyzed the relationship between drinking behavior and the genetic polymorphism(More)
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