Bente Karlund Pedersen

Learn More
OBJECTIVE Type 2 diabetes is characterized by insulin resistance with a relative deficiency in insulin secretion. This study explored the potential communication between insulin-resistant human skeletal muscle and primary (human and rat) β-cells. RESEARCH DESIGN AND METHODS Human skeletal muscle cells were cultured for up to 24 h with tumor necrosis(More)
The present study was undertaken to define the effect ofLegionella pneumophila protease on natural killer (NK) cell function in vitro. Lysis of target cells by human NK cells was determined using a51Cr-release assay. The protease inhibited the NK cell cytolytic activity in a concentration- and time-dependent manner. The inhibitory effect of the protease was(More)
RESEARCH DESIGN AND METHODS—Human skeletal muscle cells were cultured for up to 24 h with tumor necrosis factor (TNF)-a to induce insulin resistance, and mRNA expression for cytokines was analyzed and compared with controls (without TNF-a). Conditioned media were collected and candidate cytokines were measured by antibody array. Human and rat primary(More)
  • 1