Benoit Maillot

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Integration of the HIV-1 cDNA into the human genome is catalyzed by the viral integrase (IN) protein. Several studies have shown the importance of cellular cofactors that interact with integrase and affect viral integration and infectivity. In this study, we produced a stable complex between HIV-1 integrase, viral U5 DNA, the cellular cofactor LEDGF/p75 and(More)
Fluid flow in the Earth's crust plays an important role in a number of geological processes, and such flow is usually believed to be controlled by open macro-fractures in at least carbonate reservoirs. The movement of fluids in the fractured media will result in changes on the pore pressure and consequently will cause changes to the effective stress,(More)
Biological small-angle X-ray scattering (BioSAXS) is a powerful technique to determine the solution structure, particle size, shape and surface-to-volume ratio of macromolecules. However, a drawback is that the sample needs to be monodisperse. To ensure this, size-exclusion chromatography (SEC) has been implemented on many BioSAXS beamlines. Here, the(More)
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