Benoît R. Mâsse

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We did a systematic review and meta-analysis of observational studies of the risk of HIV-1 transmission per heterosexual contact. 43 publications comprising 25 different study populations were identified. Pooled female-to-male (0.04% per act [95% CI 0.01-0.14]) and male-to-female (0.08% per act [95% CI 0.06-0.11]) transmission estimates in high-income(More)
BACKGROUND Recent increases in bacterial sexually transmitted infections (STI) and risk behavior have coincided with the introduction of antiretroviral therapy (ART) in homosexual communities of industrialized countries. The reasons for these increases are not fully understood. GOAL The goal of this study was to understand the various effects of ART on(More)
BACKGROUND The Russian HIV-1 epidemic has been driven by injection drug use. OBJECTIVE To determine HIV incidence and identify demographic and behavioral correlates of infection to facilitate the development of longitudinal HIV prevention programs. METHODS In 2002, a cohort of 520 injection drug users (IDU) in St Petersburg, Russia were recruited and(More)
OBJECTIVES To evaluate the preparedness for phase 2/IIb/III microbicide trials at 4 clinical trial sites: Durban and Hlabisa (South Africa), Lusaka (Zambia), and Moshi (Tanzania). DESIGN A prospective cohort study was undertaken to assess site suitability for microbicide efficacy studies. Study objectives included assessing sites' ability to recruit and(More)
In this paper, new measures of centrality that summarize the contact structure of social networks are proposed. The new measures use a cumulative nomination scheme based on the preliminary assumption that more central individuals will be nominated more often. Some of these measures are defined to characterize networks of different sizes and, by extension,(More)
OBJECTIVES Few studies of topical microbicides have assessed their safety in HIV-infected women. We conducted this study to evaluate the safety and acceptability of 6% cellulose sulfate (CS) gel as a vaginal microbicide in sexually abstinent and active HIV-infected women. METHODS Fifty-nine HIV-infected women were enrolled in a randomized double-blind(More)
The rigorous evaluation of the impact of combination HIV prevention packages at the population level will be critical for the future of HIV prevention. In this review, we discuss important considerations for the design and interpretation of cluster randomized controlled trials (C-RCTs) of combination prevention interventions. We focus on three large C-RCTs(More)
OBJECTIVES To determine the aetiology of urethritis in Bangui, Central African Republic. METHODS 410 men presenting with urethral discharge and 100 asymptomatic controls were enrolled. Urethral swabs were obtained and processed by gonococcal culture and polymerase chain reaction for the detection of Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma(More)
OBJECTIVE To determine the safety and effectiveness of BufferGel and 0.5% PRO2000 microbicide gels for the prevention of male-to-female HIV transmission. DESIGN Phase II/IIb, randomized, placebo-controlled trial with three double-blinded gel arms and an open-label no gel arm. METHODS Study participants from Malawi, South Africa, Zambia, Zimbabwe, and(More)