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The proto-oncogene RAS, coding for a 21 kDa protein (p21), is mutated in 20% of lung cancer. However, the literature remains controversial on its prognostic significance for survival in lung cancer. We performed a systematic review of the literature with meta-analysis to assess its possible prognostic value on survival. Published studies on lung cancer(More)
The quality and availability of eye tracking equipment has been increasing while costs have been decreasing. These trends increase the possibility of using eye trackers for entertainment purposes. Games that can be controlled solely through movement of the eyes would be accessible to persons with decreased limb mobility or control. On the other hand, use of(More)
The role of the anti-apoptotic protein Bcl-2 in lung cancer remains controversial. In order to clarify its impact on survival in small and non-small cell lung cancer (NSCLC), we performed a systematic review of the literature. Trials were selected for further analysis if they provided an independent assessment of Bcl-2 in lung cancer and reported analysis(More)
The <i>VirHKey</i> is a new text entry method for mobile devices using a simple <i>Unistroke</i>-like alphabet. Gesture recognition is accomplished not through pattern recognition but through sequences of flicks with low required angular accuracy: 2p/5 in radians. This means that the full stroke path is unimportant and recognition is highly deterministic,(More)
Among new biological markers that could become useful prognostic factors for lung carcinoma, Ki-67 is a nuclear protein involved in cell proliferation regulation. Some studies have suggested an association between Ki-67 and poor survival in lung cancer patients. In order to clarify this point, we have performed a systematic review of the literature, using(More)
In order to determine whether angiogenesis is a prognostic marker in lung cancer, we performed a systematic review of the literature to assess the prognostic value on survival of microvessel count in patients with lung cancer. Published studies were identified by an electronic search in order to aggregate survival results, after a methodological assessment(More)
In this paper, we deal with new environment to visualise and to interact with cellular automata implemented in a grid of the hyperbolic plane. We use two kinds of tiling: the ternary heptagrid and the rectangular pentagrid. We show that both grids have the same spanning tree: the same numbering with maximal Fibonacci numbers can be used to identify all(More)
We propose a new technique to help users to explore geometric shapes without vision. This technique is based on a guidance using directional cues with a pin array. This is an alternative to the usual technique that consists of raising the pins corresponding to dark pixels around the cursor. In this paper we compare the exploration of geometric shapes with(More)
PURPOSE A systematic review of the literature was carried out to determine the role of prophylactic cranial irradiation (PCI) in small cell lung cancer (SCLC). METHODS To be eligible, full published trials needed to deal with SCLC and to have randomly assigned patients to receive PCI or not. Trials quality was assessed by two scores (Chalmers and ELCWP).(More)
Genetic factors are believed to be involved in the aetiology of unipolar depressive disorders. We have previously described a model built up by selective breeding of mice with different responses in the tail suspension test, a screening test for potential antidepressants. In this model, helpless H/Rouen mice are essentially immobile in this test, as well as(More)