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RATIONALE The endocannabinoid system plays a role in mediating the appetitive value of a variety of reinforcing compounds, either natural rewards or drugs of abuse, but little is known about its involvement in the incentive properties of nicotine. OBJECTIVES The objective of the study is to evaluate whether activation of CB1 cannabinoid receptors is(More)
RATIONALE We previously reported that the CB1 cannabinoid receptor antagonist, rimonabant, impaired the acquisition and the short-term (24 h), but not long-term (3 weeks), expression of conditioned place preference (CPP) induced by nicotine in rats. OBJECTIVE To assess the time interval of efficacy of a single pretest injection of rimonabant to abolish(More)
RATIONALE The noradrenergic system might be a critical mediator of psychostimulants and opiates hedonic value. OBJECTIVES The objective of this study is to evaluate the involvement of alpha1-adrenoceptors (alpha1-ARs) in nicotine incentive learning. MATERIALS AND METHODS Rats, subjected to an unbiased conditioned place preference (CPP) procedure,(More)
Although smoking prevalence has declined in recent years, certain subpopulations continue to smoke at disproportionately high rates and show resistance to cessation treatments. Individuals showing cognitive and affective impairments, including emotional distress and deficits in attention, memory, and inhibitory control, particularly in the context of(More)
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