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Challenges in real-time process optimization mainly arise from the inability to build and adapt accurate models for complex physico-chemical processes. This paper surveys different ways of using measurements to compensate for model uncertainty in the context of process optimization. Three approaches can be distinguished according to the quantities that are(More)
Coupling an anaerobic digester to a microalgal culture has received increasing attention as an alternative process for combined bioenergy production and depollution. In this article, a dynamic model for anaerobic digestion of microalgae is developed with the aim of improving the management of such a coupled system. This model describes the dynamics of(More)
This paper presents a decomposition approach for a quite general class of mixed-integer dynamic optimization problems that is capable of guaranteeing a global solution despite the nonconvexities inherent to the dynamic optimization subproblems. A case study is presented in connection to the optimal design and operation of a batch process consisting of a(More)
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract. Theory and implementation for the global optimization of a wide(More)
In this paper, the design of probabilistic observers for mass-balance based bioprocess models is investigated. It is assumed that the probability density of every uncertain parameter, input and/or initial state is known a priori. Then, the probability density of the state variables is obtained, at any time, by considering the image of this initial(More)
9.1 Introduction The focus of this chapter is on describing procedures for the optimal design and operation of man-portable power generation processes. For a given power demand, or a power demand varying in a specified range, the design and operation problem is to determine values of the design variables (e.g., sizes of the individual components such as(More)