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PEN-2 and APH-1 Coordinately Regulate Proteolytic Processing of Presenilin 1*
Presenilin (PS, PS1/PS2) complexes are known to be responsible for the intramembranous γ-secretase cleavage of the β-amyloid precursor protein and signaling receptor Notch. PS holoprotein undergoesExpand
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  • Open Access
Presenilin-1 Regulates Intracellular Trafficking and Cell Surface Delivery of β-Amyloid Precursor Protein*
Presenilins (PS1/PS2) play a critical role in proteolysis of β-amyloid precursor protein (βAPP) to generate β-amyloid, a peptide important in the pathogenesis of Alzheimer's disease. Nevertheless,Expand
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Cationic colloidal gold staining of acidic glycoconjugates in mouse Paneth cells.
The acidic glycoconjugates of mouse ileum Paneth cells were examined with the aid of light and electron microscopy, using cationic colloidal gold (CCG) as a probe. Specimens of mouse ilea were fixedExpand
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