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The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.
TLDR
These data show a selective in vivo requirement for Glut1 in metabolic reprogramming of CD4 T cell activation and Teff expansion and survival and a selection of Treg cells that appeared functionally unaffected and able to suppress Teff, irrespective of Glut 1 expression.
Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo.
TLDR
It is demonstrated that allogeneic EPC infusions can augment hematopoiesis and suggest a relationship between BM microvascular recovery and he matopoietic reconstitution in vivo.
Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease.
TLDR
A novel strategy to selectively prevent GVHD by depleting CD62L(+) T cells (naive and a subset of memory T cells) by allowing transfer of allogeneic recall antitumor and antimicrobial immunity without causing graft-versus-host disease.
Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice.
TLDR
It is demonstrated that recombinant human growth hormone can accelerate phenotypic and functional immune reconstitution following allogeneic T-cell-depleted bone marrow transplantation in mice.
Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice.
TLDR
It is suggested that reestablishment of endothelial cell activity can improve the hematopoietic recovery and survival of irradiated mice and be associated with increased survival compared with controls.
High-resolution in vivo imaging of blood vessels without labeling.
TLDR
It is shown that excellent contrast from hemoglobin without any labeling can be obtained in tissue and that both oxyhemoglobin and deoxyhemoglobin have sequential two-color, two-photon absorption properties that can serve as endogenous contrasts in microvasculature imaging.
Prophylaxis and treatment of acute graft-versus-host disease.
TLDR
Success in prophylaxis and treatment of GVHD will depend on whether GV HD can be prevented without losing anti-malignancy and anti-infectious effects, and better understanding of the allogeneic response will facilitate the development of such an approach.
Alloimmune Lung Injury Induced by Local Innate Immune Activation Through Inhaled Lipopolysaccharide
TLDR
A critical role for localized, environmentally induced innate immune activation in promoting alloimmune lung injury is demonstrated and local inhibition of TLR4 signaling in pulmonary resident hematopoietic cells represents a novel and potentially important therapeutic target to prevent posttransplant rejection.
Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process.
TLDR
The data suggest that PDP can selectively deplete host alloantigen-specific T cells for GVHD prevention and immune and antileukemia function preserve.
The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation.
TLDR
The critical role of hematopoietic cells and alveolar macrophages in initiating LPS-induced neutrophil recruitment from the vascular space to the airspace is demonstrated.
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