Benjamin Schwindenhammer

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Gastrointestinal stromal tumors (GIST) are characterized by activating mutations of KIT or platelet-derived growth factor receptor α(PDGFRA), which can be therapeutically targeted by tyrosine kinase inhibitors (TKI) such as imatinib. Despite long-lasting responses, most patients eventually progress after TKI therapy. The calcium-dependent chloride channel(More)
Angiosarcomas are rare malignant mesenchymal tumors of endothelial differentiation. The clinical behavior is usually aggressive and the prognosis for patients with advanced disease is poor with no effective therapies. The genetic bases of these tumors have been partially revealed in recent studies reporting genetic alterations such as amplifications of MYC(More)
BACKGROUND Hyperthermic isolated limb perfusion with tumor necrosis factor-α and melphalan (TM-HILP) has been successfully used to treat limb soft tissue sarcomas (STSs) with high response rates. The data on the effectiveness of HILP-TM for the treatment of STSs are mainly based on various STS types. The aim of this study was to investigate the responses of(More)
Membrane-permeable 8-(4-chlorophenylthio)-2'-O-methyl cyclic AMP (8-pCPT-2'-O-Me-cAMP) has been shown to specifically activate cAMP-regulated Epac proteins, without direct effects on protein kinase A and protein kinase G. During isometric tension measurements in thoracic aortic rings from Wistar rats, we observed that 8-pCPT-2'-O-Me-cAMP selectively induced(More)
Trabectedin has mostly been studied in metastatic leiomyosarcoma and liposarcomas. Only limited data are available in other sarcoma subtypes, heavily pretreated and elderly patients. We retrospectively analyzed 101 consecutive sarcoma patients treated with trabectedin at our center. We recorded progression-free survival (PFS), clinical benefit rate (CBR,(More)
http://dx.doi.org/10.1016/j.actbio.2015.05.029 1742-7061/ 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. DOI of original article: http://dx.doi.org/10.1016/j.actbio.2014.11.051 ⇑ Corresponding author at: Experimental Surgery and Regenerative Medicine, Department of Trauma Surgery, Campus Innenstadt, Munich University Hospi(More)
The detection of peptides from the calcitonin (CT) family in the periarticular tissue of loosened implants has raised hopes of opening new regenerative therapies in the process of aseptic loosening, which remains the major cause of early implant failure in endoprosthetic surgery. We have previously shown the roles of α-calcitonin gene-related peptide(More)
Die isolierte Extremitätenperfusion (ILP) mit TNF-α und Melphalan (TM-ILP) ist eine der effektivsten Behandlungsmodalitäten nichtresektabler Weichgewebesarkome (WGS) der Extremitäten. Liposarkome (LS) sind eine heterogene Subgruppe und anteilig mit die häufigsten WGS mit unterschiedlichem biologischem Verhalten und unterschiedlicher Prognose. Ziel der(More)
Chirurg 2017 · 88:437 DOI 10.1007/s00104-017-0424-1 Online publiziert: 6. April 2017 © Springer Medizin Verlag GmbH 2017 L. E. Podleska · B. Schwindenhammer · F. Grabellus · S. Bauer · H.-U. Steinau · G. Taeger 1 Sektion Sarkomchirurgie, Klinik für Allgemein-, Viszeralund Transplantationschirurgie, Universitätsklinikum Essen, Westdeutsches Tumorzentrum(More)
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