Benjamin Schroeder

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BACKGROUND Detailed multimodality assessment of subclinical atherosclerosis in asymptomatic subjects referred for risk stratification has not been performed. We analyzed the detection of early atherosclerosis using 3 imaging modalities: coronary artery calcium (CAC) scoring, carotid ultrasound (US), and coronary computed tomography angiography (CCTA). (More)
Physically based sound models have a “natural” setting in dimensional space: a physical model has a shape and an extent and can be given a position relative to other models. In our experimental system, we place procedurally animated agents in a world of spatially situated physical models. The agents move in the same space as the models and can interact with(More)
Enhanced activity of the Ser/Thr protein kinase, RSK, is associated with transformation and metastasis, which suggests that RSK is an attractive drug target. The natural product, SL0101 (kaempferol 3-O-(3″,4″-di-O-acetyl-α-L-rhamnopyranoside), has been shown to be a RSK selective inhibitor. However, the Ki for SL0101 is 1 μM with a half-life of less than 30(More)
Si heteroepitaxy on CaF2 was studied with x-ray photoelectron spectroscopy and diffraction and low-energy electron diffraction to determine the interface bonding and silicon overlayer growth mode. The CaF2 surface was prepared by irradiation with low-energy electrons and exposure to arsenic, which replaced surface fluorine atoms with arsenic. Thin Si films(More)
The bleomycins (BLMs) are clinically used glycopeptide antitumor antibiotics that have been shown to mediate the sequence-selective oxidative damage of both DNA and RNA. Previously, we described the solid-phase synthesis of a library of 108 unique analogues of deglycoBLM A6, a congener that cleaves DNA analogously to BLM itself. Each member of the library(More)
Dual conformational restriction: a new, highly constrained modification of the α-L-locked nucleic acid (α-L-LNA) scaffold that locks the sugar furanose ring in an N-type configuration and also restricts rotation around torsion angle γ was synthesized. This new modification increases the thermostability of an oligonucleotide duplex compared to using a single(More)
Directing a group behavior towards interesting and complex motion can and should be intuitive, iterative, and often participatory. Toward this end, we present a choreographic system that enables designers to explore a motion space based on a parametric model of behaviors. Designers may work with the system by moving back and forth through two complementary(More)
Biotin is involved in many vital metabolic pathways and must be provided for an efficient fermentation in the rumen, as well as for the intermediary metabolism of the host animal. Factors influencing ruminal biotin metabolism and output are widely unknown at present. Therefore, dairy cows fitted with permanent cannulas in the dorsal rumen and in the(More)
S. Meng, A. Bostwick, B.R. Schroeder, E. Rotenberg, F.S. Ohuchi, and M.A. Olmstead Department of Physics, University of Washington, Seattle, Washington 98195 USA Advanced Light Source, Ernest Orlando Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720 USA Department of Materials Science and Engineering, University of(More)