Benjamin S. Hsiao

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Extracellular and intracellular barriers typically prevent non-viral gene vectors from having an effective transfection efficiency. Formulation of a gene delivery vehicle that can overcome the barriers is a key step for successful tissue regeneration. We have developed a novel core-shelled DNA nanoparticle by invoking solvent-induced condensation of plasmid(More)
A unique class of polyurethane (PU) elastomer containing inorganic molecules (polyhedral oligomeric silsesquioxane, POSS) as molecular reinforcement in the hard segment was investigated by means of wide-angle X-ray diffraction (WAXD) and small-angle X-ray scattering (SAXS) techniques. WAXD results indicate that POSS molecules form nanoscale crystals showing(More)
Random copolymers of methyl methacrylate with polyhedral oligomeric silsesquioxane (POSS) were synthesized and blended with PS and PMMA homopolymer thin films. The effects of the POSS on phase segregation were studied using a variety of complementary techniques. The results showed that these copolymers were efficient at compatibilizing immiscible polymer(More)
On-line studies of structural development during continuous drawing of nylon 66 fiber at different temperatures were carried out using synchrotron wide-angle X-ray diffraction (WAXD). A unique image analysis method was introduced to analyze the two-dimensional (2D) WAXD patterns. The quantitative fractions of crystal, mesomorphic and amorphous phases were(More)
The isothermal crystallization of poly(ethylene terephthalate) (PET) homopolymers with different molecular weight was studied in a wide temperature range (140–230 °C) using different experimental techniques. Three different morphological regions, labeled r 1 , r 2 and r 3 , were distinguished as a function of crystallization temperature (T c). In r 1 (low T(More)
Despite the enormous potential in bioinspired fabrication of high-strength structure by mimicking the spinning process of spider silk, currently accessible routes (e.g., microfluidic and electrospinning approaches) still have substantial function gaps in providing precision control over the nanofibrillar superstructure, crystalline morphology or molecular(More)
The demand for multipurpose , high-performance polymer systems has resulted in a need for advancing polymer properties beyond what traditional systems can offer. Only through control/alteration at the molecular level can one maximize property enhancements to meet current military and commercial needs. Over the last seven years the Air Force Research(More)