Benjamin R Roman

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BACKGROUND In the neck, the recipient vessels most frequently used for microsurgical reconstruction are compromised by prior surgery and radiation. METHODS We conducted a retrospective chart review of all patients who underwent microvascular reconstruction between July 2001 and June 2005. Donor vessels, vein grafts, and flap survival were examined. (More)
The purpose of the STARK study (Short-Term Adherence Research in Kenya) was to identify factors that predict adherence to short-term drug regimens in Nairobi, Kenya. The participants (N = 357) in the study were recruited from the RAFIKI Foundation Clinic, a free primary healthcare clinic in Kibera, Nairobi's largest slum. Quantitative surveys were(More)
OBJECTIVES/HYPOTHESIS Ischemic necrosis of the tongue is a rare entity generally associated with vasculitis. Critically ill patients with shock might experience hypoperfusion of head and neck end organs including the tongue. STUDY DESIGN Retrospective analysis of hospital charts. METHODS Case histories and photographs of five patients who developed(More)
Spinobulbar muscular atrophy is a neurodegenerative disorder caused by expansion of a CAG triplet repeat sequence encoding a polyglutamine tract in the androgen receptor. It has been shown that the mutant protein is toxic in cell culture and triggers an apoptotic cascade resulting in activation of caspase-3. We developed an assay of caspase-3 activation in(More)
OBJECTIVE Radiotherapy, an essential modality in cancer treatment, frequently induces fibrotic processes in the skin, including accumulation of extracellular matrix. Transforming growth factor-β is essential in regulating extracellular matrix gene expression and is dependent on Smad3, an intracellular mediator/transcription factor. Our study characterized(More)
We have a hard time changing what we do in medicine. Even after new treatments are shown to be effective, they are not suddenly embraced but are usually adopted in stages—first by the innovators, then the early adopters, and only over time by the laggards (1). However, deadoption may be even slower. As hard as it seems to get people to adopt new practices,(More)
OBJECTIVE To determine whether intraoperative neural response telemetry (tNRT) is predictive of postoperative speech perception. STUDY DESIGN Retrospective review. SETTING Tertiary referral center. PATIENTS Children (n = 24) aged between 5 and 17 years and adults 18 years and older (n = 73) with severe-to-profound hearing loss and implanted with the(More)
BACKGROUND There has been increasing interest in the primary surgical treatment of patients with early T classification (T1-T2) oropharyngeal squamous cell carcinoma (OPSCC), with the stated goal of de-escalating or avoiding adjuvant treatment. Herein, the authors sought to determine the degree to which this interest has translated into changes in practice(More)
Importance Recurrent and/or metastatic head and neck cancer is usually incurable. Implementation of precision oncology for these patients has been limited by incomplete understanding of the molecular alterations underlying advanced disease. At the same time, the molecular profiles of many rare head and neck cancer types are unknown. These significant gaps(More)
Lying in bed talking to my wife one night last year, I suddenly couldn’t hear what she was saying. No, this was not a case of selective deafness. One second everything was fine, and the next, my right ear started ringing, loudly. Coincidentally, I am an otolaryngologist, and so I had two initial thoughts: “I have sudden sensorineural hearing loss” and “No(More)