Benjamin Mayer

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MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression and specific mircoRNA "fingerprints" are thought to contribute to and/or reflect certain disease conditions. Recently, we identified surprisingly homogeneous signatures of circulating miRNAs in the serum of familial amyotrophic lateral sclerosis (ALS) patients, which were already(More)
Knowledge about the nature of pathomolecular alterations preceding onset of symptoms in amyotrophic lateral sclerosis is largely lacking. It could not only pave the way for the discovery of valuable therapeutic targets but might also govern future concepts of pre-manifest disease modifying treatments. MicroRNAs are central regulators of transcriptome(More)
The GGGGCC-hexanucleotide repeat expansion in C9orf72 is the most common genetic cause of familial amyotrophic lateral sclerosis and frontotemporal dementia. This study determined the frequency of C9orf72 repeat expansions in different motor neuron diseases (amyotrophic lateral sclerosis (ALS), motor neuron diseases affecting primarily the first or the(More)
Mutations in the optineurin (OPTN) gene have been associated with normal tension glaucoma and with amyotrophic lateral sclerosis (ALS). Here, we screened German familial ALS cases for OPTN mutations to gain additional insight into the spectrum and pathogenic relevance of this gene for ALS. One hundred familial German ALS cases and 148 control subjects were(More)
BACKGROUND AND AIMS Great efforts have been made to predict disease behavior over time and the response to treatment in Crohn's disease (CD). Such understanding could personalize therapy. Early introduction of more aggressive therapies to patients at high risk and no introduction of predictable refractory treatments could become possible. We hence tested(More)
Modern science is often conducted on large scale, distributed, heterogeneous and high-performance computing infrastructures. Increasingly, the scale and complexity of both the applications and the underlying execution platforms have been growing. Scientific workflows have emerged as a flexible representation to declaratively express complex applications(More)
Adaptive study designs Animal studies Sample size calculatioin Pilot projects Animal experiments are a core element of basic medical research. Their accurate planning regarding sample size, however, poses a challenge from a biometrical point of view, since valid information is rarely given. One proposed concept includes the integration of pilot projects in(More)
PURPOSE Minimally invasive interventions offer benefits for patients, while also entailing drawbacks for surgeons, such as the loss of depth perception. Thus estimating distances, which is of particular importance in gastric bypasses, becomes difficult. In this paper, we propose an approach based on stereo endoscopy that segments organs on-the-fly and(More)
Suicidality is common among individuals at risk of psychosis. Emerging findings suggest that mental illness stigma contributes to suicidality. However, it is unclear whether stigma variables are associated with suicidality among young people at risk of psychosis. This longitudinal study assessed perceived public stigma and the cognitive appraisal of stigma(More)