Benjamin L Sherman

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The ligands for many olfactory receptors remain largely unknown despite successful heterologous expression of these receptors. Understanding the molecular receptive range of olfactory receptors and deciphering the olfactory recognition code are hampered by the huge number of odorants and large number of olfactory receptors, as well as the complexity of(More)
The large number of olfactory receptors (ORs) expressed by various mammalian and insect species, as well as the large number of potential odorant ligands, has made the pairing of odorants with receptors -(de-orphaning) exceedingly difficult. These efforts are further complicated by difficulties in expressing ORs in many standard expression systems. Xenopus(More)
Using density functional theory molecular dynamics simulations, we predict shock Hugoniot curves of precompressed methane up to 75 000 K for initial densities ranging from 0.35 to 0.70 g cm −3. At 4000 K, we observe the transformation into a metallic, polymeric state consisting of long hydrocarbon chains. These chains persist when the sample is quenched to(More)
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