Benjamin Kersten

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A wide-bore capillary gas chromatographic method has been developed to study the drug matrix effect on the determination of residual solvents in bulk pharmaceuticals. A selective method is achieved on a Restek wide-bore (0.53-mm i.d. x 30 m) open-tubular fused-silica column coated with a 5-micron film of 95% dimethyl-5% diphenyl polysiloxane protected by a(More)
We propose in this paper an iterative method composed of three steps to derive architecture alternativesfrom quality requirements using acatalogue of patterns and styles. The solution candidates are chosen by answering aset of questionswhich reflects the requirements. We instantiate then the solution candidates using aU ML-based enhancement of the problem(More)
An ion-pairing high-performance liquid chromatographic method has been developed for the determination of 5-aminosalicylic acid (5-ASA) bulk chemical in the presence of thirteen potential synthetic process impurities. In addition, the method is suitable for the determination of the in process intermediate, 5-nitrosalicylic acid. A selective method was(More)
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