Skip to search formSkip to main contentSkip to account menu
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
TLDR
It is found that CTLs inefficiently lysed primary cells infected with HIV-1 if the viral nef gene product was expressed and Nef protected infected cells by reducing the epitope density on their surface.
View on Nature
Predominant Mode of Human Immunodeficiency Virus Transfer between T Cells Is Mediated by Sustained Env-Dependent Neutralization-Resistant Virological Synapses
TLDR
The polarized T-cell morphology, Env-CD4 coordinated adhesion, and viral transfer from HIV-infected to uninfected cells suggest that VS allows HIV-1 to evade antibody neutralization and to disseminate efficiently.
View on Publisher
Quantitative 3D Video Microscopy of HIV Transfer Across T Cell Virological Synapses
TLDR
HIV dissemination may be enhanced by virological synapse-mediated cell adhesion coupled to viral endocytosis, as shown by rapid formation of micrometer-sized “buttons” containing oligomerized viral Gag protein.
View on Publisher
Sequence of Human Immunodeficiency Virus Type 1 (HIV-1) Gag Localization and Oligomerization Monitored with Live Confocal Imaging of a Replication-Competent, Fluorescently Tagged HIV-1
TLDR
A replication-competent HIV type 1 molecular clone that carries a Gag-internal or interdomain green fluorescent protein (iGFP) fusion to reveal a physiologically accurate temporal sequence of Gag localization and oligomerization during the formation of infectious HIV.
View on ASMUSA
Convalescent plasma treatment of severe COVID-19: a propensity score-matched control study.
TLDR
Convalescent plasma is potentially effective against COVID-19, but adequately powered, randomized controlled trials are needed.
View on PubMed
Human immunodeficiency virus (HIV)‐1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein‐1 expression: Implications for the pathogenesis of HIV/hepatitis…
TLDR
A potential role of HIV in liver fibrosis/inflammation mediated through effects on HSCs is suggested and the role of early highly active antiretroviral therapy initiation in patients with HIV/HCV coinfection warrants further investigation.
View on Wiley
Multiploid Inheritance of HIV-1 during Cell-to-Cell Infection
TLDR
It is suggested that cell-to-cell infection may explain the high copy numbers of proviruses found in infected cells in vivo and may provide a mechanism through which HIV preserves sequence heterogeneity in viral quasispecies through genetic complementation.
View on Publisher
Cell-to-cell transfer of HIV-1 via virological synapses leads to endosomal virion maturation that activates viral membrane fusion.
View on PubMed
Host Control of HIV-1 Parasitism in T Cells by the Nuclear Factor of Activated T Cells
View on Elsevier
IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein
View on Elsevier
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License