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HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
- K. Collins, Benjamin K. Chen, S. Kalams, B. Walker, D. Baltimore
- Biology, MedicineNature
- 22 January 1998
It is found that CTLs inefficiently lysed primary cells infected with HIV-1 if the viral nef gene product was expressed and Nef protected infected cells by reducing the epitope density on their surface.
Predominant Mode of Human Immunodeficiency Virus Transfer between T Cells Is Mediated by Sustained Env-Dependent Neutralization-Resistant Virological Synapses
The polarized T-cell morphology, Env-CD4 coordinated adhesion, and viral transfer from HIV-infected to uninfected cells suggest that VS allows HIV-1 to evade antibody neutralization and to disseminate efficiently.
Quantitative 3D Video Microscopy of HIV Transfer Across T Cell Virological Synapses
HIV dissemination may be enhanced by virological synapse-mediated cell adhesion coupled to viral endocytosis, as shown by rapid formation of micrometer-sized “buttons” containing oligomerized viral Gag protein.
Sequence of Human Immunodeficiency Virus Type 1 (HIV-1) Gag Localization and Oligomerization Monitored with Live Confocal Imaging of a Replication-Competent, Fluorescently Tagged HIV-1
- W. Hübner, Ping Chen, Armando Del Portillo, Yuxin Liu, R. Gordon, Benjamin K. Chen
- BiologyJournal of Virology
- 29 August 2007
A replication-competent HIV type 1 molecular clone that carries a Gag-internal or interdomain green fluorescent protein (iGFP) fusion to reveal a physiologically accurate temporal sequence of Gag localization and oligomerization during the formation of infectious HIV.
Convalescent plasma treatment of severe COVID-19: a propensity score-matched control study.
Convalescent plasma is potentially effective against COVID-19, but adequately powered, randomized controlled trials are needed.
Human immunodeficiency virus (HIV)‐1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein‐1 expression: Implications for the pathogenesis of HIV/hepatitis…
A potential role of HIV in liver fibrosis/inflammation mediated through effects on HSCs is suggested and the role of early highly active antiretroviral therapy initiation in patients with HIV/HCV coinfection warrants further investigation.
Multiploid Inheritance of HIV-1 during Cell-to-Cell Infection
- Armando Del Portillo, J. Tripodi, V. Najfeld, D. Wodarz, D. N. Levy, Benjamin K. Chen
- BiologyJournal of Virology
- 4 May 2011
It is suggested that cell-to-cell infection may explain the high copy numbers of proviruses found in infected cells in vivo and may provide a mechanism through which HIV preserves sequence heterogeneity in viral quasispecies through genetic complementation.
Cell-to-cell transfer of HIV-1 via virological synapses leads to endosomal virion maturation that activates viral membrane fusion.
Host Control of HIV-1 Parasitism in T Cells by the Nuclear Factor of Activated T Cells