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OXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization
TLDR
The collective data in cells, mice, and humans suggest that OXPAT is a marker for PPAR activation and fatty acid oxidation, which likely contributes to adaptive responses to the fatty acid burden that accompanies fasting, insulin deficiency, and overnutrition, responses that are defective in obesity and type 2 diabetes. Expand
S3-12, Adipophilin, and TIP47 Package Lipid in Adipocytes*
TLDR
It is suggested that the non-lipid droplet pools of S3-12, adipophilin, and TIP47 constitute a ready reservoir of coat proteins to permit rapid packaging of newly synthesized triacylglycerol and to maximize energy storage during nutrient excess. Expand
OP9 mouse stromal cells rapidly differentiate into adipocytes: characterization of a useful new model of adipogenesis Published, JLR Papers in Press, November 30, 2005
TLDR
The capacity of OP9 cells, a line of bone marrow-derived mouse stromal cells, to recapitulate adipogenesis is investigated, finding that OP9 differentiation is not diminished by maintenance in culture at high cell density or by long periods in continuous culture, thereby facilitating the generation of stable cell lines that retain adipogenic potential. Expand
methods OP 9 mouse stromal cells rapidly differentiate into adipocytes : characterization of a useful new model of adipogenesis
Much knowledge of adipocyte biology has been learned from cell culture models, most notably 3T3-L1 cells. The 3T3-L1 model has several limitations, including the requirement of 2 weeks to generateExpand
The Samd9L gene: transcriptional regulation and tissue-specific expression in mouse development.
TLDR
The expression of Samd9L was upregulated by calcitonin, and this was preceded by a significant increase in the expression of Rreb-1 mRNA, which assist in understanding the regulation of Sam d9L in the context of its paralogous gene, SAMD9, which harbors mutations in NFTC. Expand